Protein PTPN11 map

Identifiers
HUGO:PTPN11

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSUPPPRESSIVE_CORE_PATHWAYS

References
CASCADE:KIR2DL3
CASCADE:KIR2DL2
CASCADE:KIR2DL1
CASCADE:NKG2A
CASCADE:KIR3DL1
CASCADE:KIR2DL4
CASCADE:2B4
 NATURAL_KILLER  map
 MACROPHAGE  map
PMID:19833085, PMID:15699106, PMID:12138178
Inactivation of nuclear STAT1 occurs rapidly following binding to chromatin and activation of target gene transcription.
Subsequently STAT1 is dephosphorylated by phosphatases such as PTPN2 (TCP45) and PTPN11 (SHP2), and dephosphorylated STAT1
PMID:10358138, PMID:15713798
Human 2B4 is phosphorylated following activation and recruits PTPN11 (SHP-2). Association of SAP with h2B4 prevents recruitment of SHP-2.
PMID:12707331
There is direct correlation between SHP-2 recruitment and functional inhibition of target cell conjugation and cytotoxicity downstream of KIR3DL.
PMID:9751747
KIR2DL3, KIR2DL1, KIR2DS4, KIR3DL1, KIR3DL2, KIR2DL4 interact with SHP-2 in NK cells
and probably are phosphorylated by LCK (directly demonstrated for KIR2DL3 only).
(CL6 = KIR2DL3,CL42 =KIR2DL1, CL39 = KIR2DS4, NKAT3= KIR3DL1, NKAT4 = KIR3DL2,KIR103AS=KIR2DL4) .

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PTPN11@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PTPN11@INNATE_IMMUNE_CELL_Cytosol map → map PTPN11@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. STAT1|​pho|​ace@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​ace@INNATE_IMMUNE_CELL_Cytosol map
    2. STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map STAT1@INNATE_IMMUNE_CELL_Cytosol map