Identifiers
HUGO:AKT1 HUGO:AKT2 HUGO:AKT3
Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
References
MACROPHAGE
NATURAL_KILLER
NEUTROPHIL
CASCADE:TGFB
CASCADE:LGALS3
CASCADE:IL4
CASCADE:IL15
CASCADE:IL21
CASCADE:CSF2
CASCADE:IFNG
PMID:22703233
TGFBR2 upregulates expression of markers M2 activation as ARG1, MCR2 and LGALS3 (galecsin3) and induces AKT activation.
PMID:18250477
Galectin-3 mediate alternative activation of macrophages via activation of PI3K signaling and AKT posphorylation. And regulates expression of MRC1 probably via PI3K
PMID:11687500
Binding to second messenger lipids allows PDK1 and AKT (PKB) to interact with each other, resulting in the phosphorylation and consequent activation of AKT (PKB).
PMID:24795729
IL15 induces IFNG production via PI3K/AKT/MTOR pathway.
PI3K–AKT–mTOR pathway is required for granzyme B production downstream of IL15.
Treatment with PI3K inhibitor abrogated the priming effect. Such inhibition was also observed
with blocking mTOR and AKT, downstream signaling components of PI3K pathway,
suggesting that PI3K–AKT–mTOR pathway is critical for optimal responses of “primed” NK cells to cytokine stimulations.
PMID:12906785, PMID:19022819
AKT activates Rapamycin associated protein FRAP2 ( mTOR ) probably through Tuberin/GTP-binding protein Ras homolog enriched in brain ( RHEB ) pathway.
PMID:19109239
IL4 induces he tyrosine phosphorylation of IRS-2 via Type I IL-4 Receptors. Activated IRS2 interacts with p85 subunit of PI3K and Grb2 and activates downstrean PI3K signaling ( phosphorylation of Akt on Ser473).
PMID:20805416
In differentiating moDCs, the PI3K/Akt-dependent mTOR pathway was constitutively activated by GM-CSF
And this signaling is needful for DC differentiation.
PMID:21826665
TLR4/PI3K /AKT signaling in TAN promotes motility of cancer cells