Protein GSK3_beta_* map

Identifiers
HUGO:GSK3B

Maps_Modules
 MACROPHAGE  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
CASCADE:IFNG

References
PMID:16713974
GSK3B inhitits activation (DNA binding) of AP-1 factors.
GSK3B is activated downstrean of IFNG via PI3K pathway.
PMID:16007092
GSK3B inhibits CREB1 interaction with CBP and inhibits CREB1 dependent IL10 expression.
CREB1/CBP complex formation prevents binding CBP to RELA (p65) and inhibits downstream NF-kB signaling.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GSK3_beta_*@INNATE_IMMUNE_CELL_Cytosol map
  2. GSK3_beta_*|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. GSK3_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map GSK3_beta_*|​pho@INNATE_IMMUNE_CELL_Cytosol map
    2. GSK3_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map GSK3*@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. CREB1@INNATE_IMMUNE_CELL_Cytosol map → map CREB1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
    2. CBP*@INNATE_IMMUNE_CELL_Cytosol map + RELA@INNATE_IMMUNE_CELL_Cytosol map → map CBP*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
    3. CREB1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CBP*@INNATE_IMMUNE_CELL_Cytosol map → map CBP*:​CREB1|​pho@INNATE_IMMUNE_CELL_Cytosol map