Protein PDPK1 map

Identifiers
HUGO:PDK1

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
 MACROPHAGE  map
CASCADE:IL4
PMID:19109239
IL4 induces he tyrosine phosphorylation of IRS-2 via Type I IL-4 Receptors. Activated IRS2 interacts with p85 subunit of PI3K and Grb2 and activates downstrean PI3K signaling ( phosphorylation of Akt on Ser473)
PMID:11687500
Binding to second messenger lipids allows PDK1 and AKT (PKB) to interact with each other, resulting in the phosphorylation and consequent activation of AKT (PKB).

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PDPK1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PDPK1:​PIP3*@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. PDPK1@INNATE_IMMUNE_CELL_Cytosol map + PIP3*@INNATE_IMMUNE_CELL_Cytosol map → map PDPK1:​PIP3*@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. AKT*@INNATE_IMMUNE_CELL_Cytosol map → map AKT*|​pho@INNATE_IMMUNE_CELL_Cytosol map