Protein KIR2DS2 map

Identifiers
HUGO:KIR2DS2

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:NK_ACTIVATING_RECEPTORS

References
 NATURAL_KILLER  map
CASCADE:KIR2DS2
PMID:11015446, PMID:9655483, PMID:9490415
KIR2DS2 interacts with DAP12.
Ligation of KIR2DS2 in transfectants expressing KIR2DS2/DAP12 complexes results in the tyrosine phosphorylation of DAP12 and other cellular substrates and the association of phosphorylated DAP12 with Syk and ZAP70.
Cross-linking of the KIR2DS2/DAP12 receptor on NKL cells resulted in the dose-dependent secretion of IFN-γ and GM-CSF

KIR2DS2@INNATE_IMMUNE_CELL_Membrane

Identifiers
CHEBI:16238 KEGGCOMPOUND:C00016 CAS:146-14-5

Maps_Modules
MODULE:IMMUNE_STIMULATION MODULE:ANTIGEN_PRESENTATION MODULE:EFFECTOR_ACTIVATION

References
 DENDRITIC_CELL  map

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. KIR2DS2@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. DAP12*:​KIR2DS2@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. KIR2DS2@INNATE_IMMUNE_CELL_Membrane map + DAP12*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*:​KIR2DS2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. IFNG@INNATE_IMMUNE_CELL_Cytosol map → map IFNG@default map
  2. CSF2@INNATE_IMMUNE_CELL_Cytosol map → map CSF2@default map
  3. SYK@INNATE_IMMUNE_CELL_Cytosol map → map SYK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  4. ZAP70@INNATE_IMMUNE_CELL_Cytosol map → map ZAP70|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map