Identifiers
HUGO:IFNG
Maps_Modules
MACROPHAGE
MDSC
NATURAL_KILLER
DENDRITIC_CELL
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
MODULE:EFFECTOR_ACTIVATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
CASCADE:TGFB
CASCADE:IL4
CASCADE:KLRB1
CASCADE:IL12
CASCADE:IL15
CASCADE:KLRG1
CASCADE:KIR2DL2
CASCADE:KIR2DL4
CASCADE:NKP80
CASCADE:NKG2D
CASCADE:KIR2DS2
CASCADE:KIR3DS1
CASCADE:Fc_gamma_RIII
CASCADE:IL18
CASCADE:IL2
References
PMID:12413632
IFNG is a major factor of M1 activation of macrophages.
PMID:6425450
Monoclonal antibody to IFNG inhibits macrophage tumoricidal activities.
PMID:11964313
INFG potentiates TLR signaling and NFkB activation downstream of TLR.
PMID:9864217
IFNG cooperates with TNF and TLR signaling in NF-kB activation.
PMID:19833085
IFNG achieves strong activation effects is by enhancing macrophage
responsiveness to other inflammatory stimuli, such as TLR ligands and TNF.
PMID:14607900, PMID:16713974
IFNG impairs IL-10 anti-inflammatory activity.
PMID:10485906
IFNG downregulates IL4 signaling pathway via SOCS1.
PMID:16713974
INFG signaling inhibits p38 activation
PMID:15814715, PMID:18272812, PMID:17016554
STAT1 is involeved in immunosupresive activity of M2 macrophages and MDSC, probably downstream of IFNG.
activation of MSCs is initiated in response to IFN-gamma, presumably produced in situ by antitumor T cells in the tumor microenvironment.
PMID:16424049
The secretion of interleukin (IL)-10 and transforming growth factor-beta by Gr-1(+)CD115(+) MSCs and iNOS expression was induced and enhanced, respectively, on IFN-gamma stimulation.
PMID:11870632, PMID:9834059
Stimulation of NK cells with IL-4 inhibited IFN-gamma, but increased IL5, IL-13 expression.
NK cells stimuletad by IL4 have NK2 subtype
PMID:21149606
Nkp80 signaling induces marked IFNG production
PMID:11777960
ULBP2 through NKG2D induces SCF2 (GM-CSF), CLL4 (MIP1B) and IFNG secretion via PI3K pathway
PMID:11489965, PMID:15778339
KIR2DL4 transduces signals into human NK cells through association with the Fc receptor gamma protein. It induces IFNG production but not cytotoxicity in resting NK cells
PMID:16713974, PMID:11579131
INFG pathway inhibits activation (phosphorylation) of ERK, JNK, p38 kinases and PI3K pathway induced by TLR. Inhibition of AKT pathway by IFNG resulted in activation of GSK3. GSK3 inhibits downstream AP-1 and CREB1 signaling and downregulates IL10 expression induced by TLR.IFNG inhibits CREB activation via p38 induced by TLR signaling
→ IFNG@default
+ IFNG@INNATE_IMMUNE_CELL_Cytosol → IFNG:MIR15/16*@INNATE_IMMUNE_CELL_Cytosol
+ IFNGR1:IFNGR2@INNATE_IMMUNE_CELL_Membrane + JAK1@INNATE_IMMUNE_CELL_Cytosol + JAK2@INNATE_IMMUNE_CELL_Cytosol → IFNGR1|pho:IFNGR2:IFNG|hm2:JAK1:JAK2@INNATE_IMMUNE_CELL_Membrane
→ IMMUNE_ACTIVATION@default
→ IFNG|hm2@default
→ IFNG@INNATE_IMMUNE_CELL_Cytosol
→ MIF@default
→ ICAM1@INNATE_IMMUNE_CELL_Membrane
→ TGFB*@default
→ HMGB1@default
→ rIL18R1@INNATE_IMMUNE_CELL_Cytosol
→ rIL18RAP@INNATE_IMMUNE_CELL_Cytosol
→ NFkB*@INNATE_IMMUNE_CELL_Cytosol
→ rRELA@INNATE_IMMUNE_CELL_Cytosol
→ CD18*@INNATE_IMMUNE_CELL_Membrane
→ PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol
→ ERK1/2*|pho@INNATE_IMMUNE_CELL_Cytosol
→ rIL10@INNATE_IMMUNE_CELL_Cytosol
→ IL10@INNATE_IMMUNE_CELL_Cytosol
→ rTLR2@INNATE_IMMUNE_CELL_Cytosol
→ TLR2@INNATE_IMMUNE_CELL_Membrane
→ rTLR4@INNATE_IMMUNE_CELL_Cytosol
→ STAT1|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ rLY96@INNATE_IMMUNE_CELL_Cytosol
→ rMYD88@INNATE_IMMUNE_CELL_Cytosol
+ TNFR1*@INNATE_IMMUNE_CELL_Membrane → STAT1|pho:TNFR1*@INNATE_IMMUNE_CELL_Membrane
→ JNK*|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ p38*|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ rHIF2A*@INNATE_IMMUNE_CELL_Cytosol
→ rHIF1A@INNATE_IMMUNE_CELL_Cytosol