Protein IL12RB1 map

Identifiers
HUGO:IL12RB2

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
CASCADE:IL12
CASCADE:IL2
 NATURAL_KILLER  map
PMID:15546391
Interleukin (IL)-12 is a heterodimeric cytokine composed of two disulfide-linked subunits, p35 and p40.
This cytokine is produced by a variety cells including monocytes, neutrophils, and B cells, but the major producers of IL-12 are macrophages and dendritic cells (DCs).
The IL-12 receptor (IL-12R) is composed of two subunits termed β1 and β2, which are structurally related to the type I cytokine receptor superfamily (44–47). The affinity of IL-12 for either subunit alone is low, but coexpression of both β1 and β2 subunits generates human IL-12 high-affinity binding sites. IL-12p40 interacts predominantly with the β1 subunit, whereas p35 interacts largely with the β2 subunit.
PMID:10807786
Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IL12RB1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL12RB1:​IL12RB2@INNATE_IMMUNE_CELL_Membrane map
  2. IL12*:​IL12RB1:​IL12RB2:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL12RB1@INNATE_IMMUNE_CELL_Cytosol map → map IL12RB1@INNATE_IMMUNE_CELL_Cytosol map
  2. IL12*@default map + IL12RB1:​IL12RB2@INNATE_IMMUNE_CELL_Membrane map + JAK2@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map → map IL12*:​IL12RB1:​IL12RB2:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  3. IL12RB1@INNATE_IMMUNE_CELL_Cytosol map + IL12RB2@INNATE_IMMUNE_CELL_Cytosol map → map IL12RB1:​IL12RB2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. STAT4@INNATE_IMMUNE_CELL_Cytosol map → map STAT4|​pho@INNATE_IMMUNE_CELL_Cytosol map