Protein JAK2 map

Identifiers
HUGO:JAK2

Maps_Modules
 MACROPHAGE  map
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
 NATURAL_KILLER  map
CASCADE:IL4
CASCADE:IL13
CASCADE:IL6
CASCADE:CSF3
CASCADE:CSF2
CASCADE:IL12

References
PMID:14610620
JAK2 is a member of the Janus kinase family.
JAK2 associated with IL13RA1 participates in signal transduction.
PMID:19833085
IFNG receptor is assosiated with kinases JAK1 and JAK2
PMID:20406969, PMID:24091328, PMID:11867689
GM-CSF uniquely inhibited signal transducers and activators of transcription (STAT3) and promoted STAT5 activation, probably downstream of JAK2. STAT5ab(null/null) MDSC were rendered sensitive to sunitinib in the presence of GM-CSF in vitro.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. JAK2@INNATE_IMMUNE_CELL_Cytosol map
  2. JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CSF2:​CSF2RA:​CSF2RB:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  2. CSF3R:​GSF3:​JAK1|​pho:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  3. IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane map
  4. IL12*:​IL12RB1:​IL12RB2:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  5. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  6. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  7. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  8. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  9. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  10. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  11. IL6:​IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. JAK2@INNATE_IMMUNE_CELL_Cytosol map → map JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. IL2RG:​IL4:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK3@INNATE_IMMUNE_CELL_Cytosol map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  3. IL13RA1:​IL4:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  4. IL13:​IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK1@INNATE_IMMUNE_CELL_Cytosol map → map IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  5. IL6:​IL6R:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map IL6:​IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map
  6. CSF3R:​GSF3@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map CSF3R:​GSF3:​JAK1|​pho:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  7. IFNG|​hm2@default map + IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane map
  8. CSF2@default map + CSF2RA:​CSF2RB@INNATE_IMMUNE_CELL_Membrane map + JAK2@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map CSF2:​CSF2RA:​CSF2RB:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  9. IL4@default map + IL2RG:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK3@INNATE_IMMUNE_CELL_Cytosol map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  10. IL4@default map + IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map → map IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  11. IL13@default map + IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane map + JAK2@INNATE_IMMUNE_CELL_Cytosol map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map → map IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  12. IL12*@default map + IL12RB1:​IL12RB2@INNATE_IMMUNE_CELL_Membrane map + JAK2@INNATE_IMMUNE_CELL_Cytosol map + TYK2@INNATE_IMMUNE_CELL_Cytosol map → map IL12*:​IL12RB1:​IL12RB2:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@default map
  2. gTIMP3@INNATE_IMMUNE_CELL_Cytosol map → map rTIMP3@INNATE_IMMUNE_CELL_Cytosol map
  3. STAT3@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  4. IRS2@INNATE_IMMUNE_CELL_Cytosol map → map IRS2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  6. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  7. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol map → map rIL12p40*@INNATE_IMMUNE_CELL_Cytosol map
  8. gIL23A@INNATE_IMMUNE_CELL_Cytosol map → map rIL23A@INNATE_IMMUNE_CELL_Cytosol map
  9. gIL18@INNATE_IMMUNE_CELL_Cytosol map → map rIL18@INNATE_IMMUNE_CELL_Cytosol map
  10. gINHBA@INNATE_IMMUNE_CELL_Cytosol map → map rINHBA@INNATE_IMMUNE_CELL_Cytosol map
  11. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  12. STAT6@INNATE_IMMUNE_CELL_Cytosol map → map STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  13. STAT5*@INNATE_IMMUNE_CELL_Cytosol map → map STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  14. STAT4@INNATE_IMMUNE_CELL_Cytosol map → map STAT4|​pho@INNATE_IMMUNE_CELL_Cytosol map