Protein TGFB1 map

Identifiers
HUGO:TGFB1

Maps_Modules
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
MODULE:EFFECTOR_INHIBITION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_EXPRESSION
 MACROPHAGE  map
 MDSC  map
 NATURAL_KILLER  map
 DENDRITIC_CELL  map
CASCADE:TGFB
CASCADE:STING

References
PMID:22703233
TGFB1 participates in M2 activation.
PMID:7594497
TGFB1 upregulates IL10 expression in macrophages.
TGFB1 and IL10 dowregulate expression of TNF.
PMID:21278795
TGFB-induced IRAK3 (IRAK-M) expression in tumor-associated macrophages
and inhibit TLR-dependent signaling
PMID:20644162
Cytokine-induced CD33+ human MDSCs have upregulated iNOS, TGFβ, VEGF.
PMID:19109155
MDSC inhibit cytotoxicity, NKG2D expression, and IFN-gamma production of NK cells both in vitro and in vivo.
Membrane-bound TGF-beta1 on MDSC is responsible for MDSC-mediated suppression of NK cells.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TGFB1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rTGFB1@INNATE_IMMUNE_CELL_Cytosol map → map TGFB1@INNATE_IMMUNE_CELL_Cytosol map
    2. TGFB1@INNATE_IMMUNE_CELL_Cytosol map → map TGFB*@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: