ERK1/2*

Protein ERK1/2*

Identifiers
HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3
REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1
NATURAL_KILLER
DENDRITIC_CELL
MACROPHAGE
NEUTROPHIL
CASCADE:VEGFA
CASCADE:MIF
CASCADE:NKP80
CASCADE:KIR2DS4
CASCADE:NKP46
CASCADE:Fc_gamma_RIII
CASCADE:LFA1
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
CASCADE:TLR2_4
CASCADE:IL15
CASCADE:IL2
CASCADE:IFNG
PMID:11062502, PMID:11385609, PMID:11907067, PMID:15536084
Nkp46 controls NK cytolitic activity via PI3K /RAC1/PAK1/MEK /ERK pathway, probably throught SYK
PMID:17395718, PMID:11062502, PMID:15536084
PAK1 activates classical MEK/ERK cascad resulted in granule movement and polarization and tumor cel lysis downstream of Nkp30, Syk and PI3K.
PMID:11062502, PMID:15536084
ERK1/2 activation induces perforin and granzyme B movement towards target tumor cells downstream of PI3K signaling in NK cells.
PMID:21149606
NKp80 activates PI33/ERK pathway probably via SYK.
PMID:22786724
DNAM1 induces ERK pathway probably via VAV1.
PMID:20189481
PLCG inhibitor completely abrogated synergistic Erk phosphorylation downstream of NKG2D and 2B4.
These data suggest that PLCG, rather than PI3K, is a critical upstream regulator of Erk activation in this pathway.
PMID:10849428
IL-2 and IL-15 are able to induce the phosphorylation of ERK1/2. probably via PI3K pathway.
MKK/ERK pathway is necessary for IL-2 to activate NK cells to express at least four known biological responses: LAK generation, IFN-gamma secretion, and IL2RA (CD25) and CLEC2C(CD69) expression.
PMID:10903731
IL18 signaling induces activation of ERK1/2 kinases. The cytolytic activity of NK cells downstream of IL18
is inhibited by ERK inhibitors.
PMID:20363967, PMID:16204085
Src homology 2-containing inositol 5'-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12, probably via inhibition of PI3K pathway and downstream ERK signaling.
PMID:15563472
Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells.
PMID:11489965, PMID:10843677
The IFN-γ secretion by NK cells induced by IL-2 depends on an ERK mitogen-activated protein kinase pathway.
IL-2 activation of an MKK/ERK pathway is required for NK cells to acquire enhanced cytolytic function (LAK activity).
IL-2-driven IFN-γ secretion and induction of CD25 and CD69 (CLEC2C) activation markers require intact MKK/ERK pathway.
PMID:9862693
CD16-induced ERK activation provides IFN-γ mRNA accumulation and ADCC and spontaneous cytotoxicity of NK cells
PMID:9064320
CD16-induced ERK activation provides TNFA expression in NK cells.
MEK/ERK cascade induces AP1(c-fos) phosphorylation downstream of CD16
PMID:9120268, PMID:9973479
ERK2 activates Phospholipase A2 group IIA (sPLA2 and cPLA2) by phosphorylation downstream of CD16 activation, but CDl6-induced degranulation in human NK cells is
dependent on ERK activation, but not on sPLA, or cPLA.
PMID:10679059, PMID:12626562
PTK2B, PYK2. Binding of NK cells to sensitive target cells or ligation of β2 integrins results in a rapid induction of Pyk2 phosphorylation and activation.
y contrast, no detectable Pyk2 tyrosine phosphorylation is found upon CD16 stimulation.
Pyk2 activation is a crucial event for natural but not Ab-dependent cytotoxicity.
Ligation of Beta2 integrins on NK cells resulted in Pyk2-dependent Erk activation, provavli via VAV1/RAC1 pathway.
Pyk-2-mediated control of integrin-triggered Rac-1 activation involves the regulation of Vav tyrosine phosphorylation.
PMID:9763606
Cross-linking of β1 Integrins on Human NK Cells Induces Shc Tyrosine Phosphorylation and Grb2 Association via Pyk-2end
resulted in RAS/ERK activation. Integrin-mediated Ras–Extracellular Regulated Kinase (ERK) Signaling Regulates Interferon γ Production in Human Natural Killer Cells.
PMID:15113754
LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56+CD8+ natural killer cells.
(ICAM-2) and ICAM-3 promoted LFA-1-directed perforin release, whereas ICAM-1 had little effect.
PMID:12048245
IFN-γ-Induced Gene Expression is MEKK1/p38 dependent and MEKK1/ERK dependent
MEKK1 upregulates CEBPB activation via ERK
PMID:10733514
ERK2 activated MLCK, resulting in phosphorylation of the MLCK substrate or of the myosin light chain itself.
And induces phagocytosis.
PMID:17086423
VEGF treatment enhanced the phospho-Erk 1 and 2 via KDR in DC
PMID:12782713
MIF signal transduction initiated by binding to CD74.
CD74 Mediates MIF Induction of ERK-1/2 Phosphorylation, PGE2 Production, and Proliferation in macrophages.
PMID:23508573
HMGB1 induces activation (phosphorylation) of ERK, JNK and p38 via TLR4 in macrophages
PMID:16713974, PMID:11579131
INFG pathway inhibits activation (phosphorylation) of ERK, JNK, p38 kinases and PI3K pathway induced by TLR. Inhibition of AKT pathway by IFNG resulted in activation of GSK3. GSK3 inhibits downstream AP-1 and CREB1 signaling and downregulates IL10 expression induced by TLR.IFNG inhibits CREB activation via p38 induced by TLR signaling
PMID:21826665
ERK is activated in TAN

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

ERK1/2*@INNATE_IMMUNE_CELL_Cytosol
ERK1/2*|pho@INNATE_IMMUNE_CELL_Cytosol

Participates in complexes:

Participates in reactions:
As Reactant or Product:

ERK1/2*@INNATE_IMMUNE_CELL_Cytosol → ERK1/2*|pho@INNATE_IMMUNE_CELL_Cytosol

As Catalyser: