Protein IRS2 map

Identifiers
HUGO:IRS2

Maps_Modules
 MACROPHAGE  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
CASCADE:IL4
CASCADE:IL13

References
PMID:9535722
IL13 induces phosporylation of IRS2 and PLCG1 which is probably a PLC responsible for downstream IL13 dependent Ca2+ mobilization signaling and assosiation of IRS2 and PLCG1
PMID:7890616
PCL (probably PCLG1) induces t hydrolysis of phosphoinositides and activates InsP3-induced intracellular Ca2+ release downstream of IL13.
PMID:19109239
IL4 induces he tyrosine phosphorylation of IRS-2 via Type I IL-4 Receptors.
Activated IRS2 interacts with Grb2 and activates downstrean PI3K signalin.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IRS2@INNATE_IMMUNE_CELL_Cytosol map
  2. IRS2|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. IRS2@INNATE_IMMUNE_CELL_Cytosol map → map IRS2|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. GRB2@INNATE_IMMUNE_CELL_Cytosol map → map GRB2@INNATE_IMMUNE_CELL_Cytosol map