PRF1

RNA PRF1

Identifiers
HUGO:PRF1

Maps_Modules
MODULE:TUMOR_KILLING MODULE:EFFECTOR_ACTIVATION MODULE:EXOCYTOSIS_AND_PHAGOCYTOSIS

References
NATURAL_KILLER
CASCADE:IL12
CASCADE:IL2
CASCADE:IL15
CASCADE:IFNAB
PMID:9841920
Induction of perforin mRNA by IL-2 and IL-15 was markedly decreased in Stat5b−/− splenocytes
PMID:21960590
Human miR-27a* specifically bound to the 3' untranslated regions of Prf1 and GzmB, down-regulating expression in both resting and activated NK cells.
PMID:22649192
miR-378 and miR-30e suppress IFN-α–upregulated granzyme B and perforin expression in human NK cells.
miR-378 and miR-30e are markedly decreased in activated NK cells by IFNA,
miR-378 and miR-30e directly targeted granzyme B and perforin, respectively and suppress of human NK cell cytotoxicity.
PMID:24698324
miR-150 binds to 3' untranslated regions of mouse and human Prf1, posttranscriptionally downregulating its expression.
PMID:15084276
T-bet is a key factor in the terminal maturation and peripheral homeostasis of NK and Vα14i NKT cells.
Granzyme B, perforin and Runx1 are direct and positievly regulated targets of TBX21 (T-BET) in NK cells.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

rPRF1@INNATE_IMMUNE_CELL_Cytosol

Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: