Antisense RNA MIR150 map

Identifiers
HUGO:MIR150

Maps_Modules
MODULE:TUMOR_KILLING MODULE:EFFECTOR_ACTIVATION MODULE:EXOCYTOSIS_AND_PHAGOCYTOSIS MODULE:CORE_SIGNALING_PATHWAYS MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE

References
 NATURAL_KILLER  map
CASCADE:IL15
PMID:24698324
miR-150 binds to 3' untranslated regions of mouse and human Prf1, posttranscriptionally downregulating its expression. Mouse wild-type NK cells displayed downregulated miR-150 expression in response to IL-15, which led to corresponding repression and induction of Prf1 during rest and after IL-15 activation, respectively.
Immunodeficient mice were injected with miR-150(-/-) NK cells, there was a significant reduction in tumor growth and metastasis of B16F10 melanoma.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. arMIR150@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MIR150:​PRF1@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. gMIR150@INNATE_IMMUNE_CELL_Cytosol map → map arMIR150@INNATE_IMMUNE_CELL_Cytosol map
  2. arMIR150@INNATE_IMMUNE_CELL_Cytosol map + rPRF1@INNATE_IMMUNE_CELL_Cytosol map → map MIR150:​PRF1@INNATE_IMMUNE_CELL_Cytosol map
  3. MIR150:​PRF1@INNATE_IMMUNE_CELL_Cytosol map → map degraded
As Catalyser: