RNA GZMB map

Identifiers
HUGO:GZMB

Maps_Modules
MODULE:TUMOR_KILLING MODULE:EFFECTOR_ACTIVATION MODULE:EXOCYTOSIS_AND_PHAGOCYTOSIS

References
 NATURAL_KILLER  map
PMID:24795729
PI3K–AKT–mTOR pathway is required for granzyme B production downstream of IL15
PMID:21960590
Human miR-27a* specifically bound to the 3' untranslated regions of Prf1 and GzmB, down-regulating expression in both resting and activated NK cells.
PMID:22649192
miR-378 and miR-30e suppress IFN-α–upregulated granzyme B and perforin expression in human NK cells
miR-378 and miR-30e are markedly decreased in activated NK cells by IFNA,
miR-378 and miR-30e directly targeted granzyme B and perforin, respectively and suppress of human NK cell cytotoxicity..

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rGZMB@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GZMB:​MIR223@INNATE_IMMUNE_CELL_Cytosol map
  2. GZMB:​MIR30E@INNATE_IMMUNE_CELL_Cytosol map
  3. GZMB:​MIR378@INNATE_IMMUNE_CELL_Cytosol map
  4. GZMB:​MIR27A*@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. GZMB:​MIR27A*@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  2. arMIR27A*@INNATE_IMMUNE_CELL_Cytosol map + rGZMB@INNATE_IMMUNE_CELL_Cytosol map → map GZMB:​MIR27A*@INNATE_IMMUNE_CELL_Cytosol map
  3. arMIR378@INNATE_IMMUNE_CELL_Cytosol map + rGZMB@INNATE_IMMUNE_CELL_Cytosol map → map GZMB:​MIR378@INNATE_IMMUNE_CELL_Cytosol map
  4. gGZMB@INNATE_IMMUNE_CELL_Cytosol map → map rGZMB@INNATE_IMMUNE_CELL_Cytosol map
  5. GZMB:​MIR223@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  6. GZMB:​MIR378@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  7. arMIR223@INNATE_IMMUNE_CELL_Cytosol map + rGZMB@INNATE_IMMUNE_CELL_Cytosol map → map GZMB:​MIR223@INNATE_IMMUNE_CELL_Cytosol map
  8. GZMB:​MIR30E@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  9. arMIR30E@INNATE_IMMUNE_CELL_Cytosol map + rGZMB@INNATE_IMMUNE_CELL_Cytosol map → map GZMB:​MIR30E@INNATE_IMMUNE_CELL_Cytosol map
  10. rGZMB@INNATE_IMMUNE_CELL_Cytosol map → map GZMB@SECRETORY_GRANULE map
As Catalyser: