Antisense RNA MIR223 map

Identifiers
HUGO:MIR223

Maps_Modules
MODULE:TUMOR_KILLING MODULE:EFFECTOR_ACTIVATION MODULE:EXOCYTOSIS_AND_PHAGOCYTOSIS MODULE:CORE_SIGNALING_PATHWAYS MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE

References
 NATURAL_KILLER  map
CASCADE:IL15
PMID:20935160
miR-223 was identified as a mature miRNA present in resting NK cells with decreased expression following IL15 activation. miR-223 specifically targets the 3' untranslated region of murine GzmB in vitro, indicating that this miRNA may contribute to control of GzmB translation in resting NK cells.
PMID:21939504
The shuttling of fluorescently-labeled exogenous miRNAs from IL-4-activated macrophages to co-cultivated breast cancer cells without direct cell-cell contact was observed. miR-223, a miRNA specific for IL-4-activated macrophages, was detected within the exosomes released by macrophages and was significantly elevated in the co-cultivated SKBR3 and MDA-MB-231 cells. The invasiveness of the co-cultivated breast cancer cells decreased when the IL-4-activated macrophages were treated with a miR-223 antisense oligonucleotide (ASO) that would inhibit miR-223 expression. Furthermore, results from a functional assay revealed that miR-223 promoted the invasion of breast cancer cells via the Mef2c-β-catenin

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. arMIR223@INNATE_IMMUNE_CELL_Cytosol map
In compartment: TUMOR_CELL_AS_EFFECTOR
  1. arMIR223@TUMOR_CELL_AS_EFFECTOR map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GZMB:​MIR223@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. GZMB:​MIR223@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  2. gMIR223@INNATE_IMMUNE_CELL_Cytosol map → map arMIR223@INNATE_IMMUNE_CELL_Cytosol map
  3. arMIR223@INNATE_IMMUNE_CELL_Cytosol map + rGZMB@INNATE_IMMUNE_CELL_Cytosol map → map GZMB:​MIR223@INNATE_IMMUNE_CELL_Cytosol map
  4. arMIR223@INNATE_IMMUNE_CELL_Cytosol map → map arMIR223@TUMOR_CELL_AS_EFFECTOR map
As Catalyser: