Identifiers
HUGO:NOS2
Maps_Modules
MACROPHAGE
MDSC
DENDRITIC_CELL
MODULE:TUMOR_KILLING
MODULE:EFFECTOR_ACTIVATION
MODULE:NO_ROS_PRODUCTION
CASCADE:TGFB
CASCADE:MIF
CASCADE:IL10
CASCADE:IFNG
References
PMID:17476345
NOS2, a heme-containing enzyme
that catalyzes the synthesis of NO and citrulline from l‐Arg, is
expressed by various cells of the immune system, and its activa-
tion is considered a hallmark of classically activated macrophages
(also known as M1 macrophages), a macrophage subset that pro-
duces proinflammatory cytokines and acts as the effector cell in
the killing of invading pathogens and tumor cells.
PMID:17689680, PMID:12646658
STAT1 binds to INOS promoter and induces INOS expression and NO production downstream of IFNG in murine macrophages. Acetylation inhibits STAT1 binding to promotor.().
PMID:11399519
STAT1, IRF1 and NF-kB interact with NOS2 promoter and cooperatively activate NOS2 expression in mouse macrophages (
PMID:16127449
PPARG sumoilated by PIAS1/UbC9 prevents dissociation of the NCoR–HDAC3 complex fro promoters
and transrepresses NF-kB dependent expression NOS2, Ccl3, Ccl7, Cxcl10
PMID:17689680
STAT1, IRF1 and NF-kB interact with NOS2 promoter and cooperatively activate NOS2 expression in macrophages downstteam of IFNG.
PMID:22067385
c-MYC is expressed in tumor-associated macrophages, and its inhibition blocks the expression of protumoral genes including VEGF, MMP9, HIF-1A, and TGFB.
PMID:20644162
Cytokine-induced CD33+ human MDSCs have upregulated iNOS, TGFβ, VEGF.
PMID:16424049
iNOS expression was induced by IFN-gamma stimulation in MDSC, probably via STAT1.
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD206, CD23
PMID:11875494
IL10 stimulates HO1 expression via MAPK p38 stimulation. HO-1 mediates IL-10-induced suppression of TNF- production and IL-10-induced suppression of MMP9 and INOS expression
PPARG sumoilated by PIAS1/UbC9 prevents dissociation of the NCoR–HDAC3 complex fro promoters and transrepresses expression NOS2, Ccl3, Ccl7, Cxcl10
IFNG induces INOS and IL10 expression and TGFB secretion in MDSC
PMID:24777831
IFN-γ induces the cytotoxic function of IL-4 DCs but not IL-15 DCs.
iNOS expression was induced by IFN-gamma stimulation in IL4-DC but not in IL15DC via STAT1