RNA NOS2 map

Identifiers
HUGO:NOS2

Maps_Modules
 MACROPHAGE  map
 MDSC  map
 DENDRITIC_CELL  map
MODULE:TUMOR_KILLING
MODULE:EFFECTOR_ACTIVATION
MODULE:NO_ROS_PRODUCTION
CASCADE:TGFB
CASCADE:MIF
CASCADE:IL10
CASCADE:IFNG

References
PMID:17476345
NOS2, a heme-containing enzyme
that catalyzes the synthesis of NO and citrulline from l‐Arg, is
expressed by various cells of the immune system, and its activa-
tion is considered a hallmark of classically activated macrophages
(also known as M1 macrophages), a macrophage subset that pro-
duces proinflammatory cytokines and acts as the effector cell in
the killing of invading pathogens and tumor cells.
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD206, CD23

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rNOS2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rNOS2@INNATE_IMMUNE_CELL_Cytosol map → map NOS2@INNATE_IMMUNE_CELL_Cytosol map
    2. gNOS2@INNATE_IMMUNE_CELL_Cytosol map → map rNOS2@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: