Identifiers
HUGO:ARG1
Maps_Modules
MACROPHAGE
NEUTROPHIL
MDSC
MODULE:TUMOR_KILLING
MODULE:EFFECTOR_ACTIVATION
MODULE:NO_ROS_PRODUCTION
CASCADE:LACTIC
CASCADE:TGFB
CASCADE:MIF
CASCADE:IL4
References
PMID:12193690
Up-regulation of IL4RA by IL10 correlates with increased
IL4-dependent expression of arginase-1 (ARG1).
PMID:21670502
KLF4 together with STAT6 upregulates expression of PPARG and ARG1 downstream of IL4 in macrophages.
PMID:23454751
MDSC showed high phosphorylated STAT3 levels that correlated with arginase-I expression levels and activity.
phosphorylated STAT3 binds to multiple sites in the arginase-I promoter. Rescue of arginase-I activity after STAT3 blockade restored MDSC’s suppressive function.
Taken together, these results demonstrate that the suppressive function of arginase-I in both infiltrating and circulating MDSC is a downstream target of activated STAT3.
PMID:20644162
Human MDSC express AGR1
PMID:24030977
SCF2 (GM-CSF) promotes the immunosuppressive activity of glioma-infiltrating myeloid cells (MDSC) through upregulation of expression of interleukin-4 receptor-α
ARG1, TGFB, COX2 expression is downregulated in IL4R-/- MDSC (probably via STAT3 and MYC).
PMID:12496409
Arg1 is up-regulated in MDSC by IL-4.
Arg1 increases superoxide production in myeloid cells through a pathway that likely utilizes the reductase domain of inducible NO synthase (iNOS), and that superoxide is required for Arg1-dependent suppression of T cell function.
PMID:25043024
Lactic acid is sufficient to induce Vegf and Arg1 via HIF1α.
Lactic acid, probably via HIF1A polarizes macrophages to an M2-Iike state that is critical for tumour growth
19732719
Inhibition of TGF-ß signaling downregulates Arginase1, CCL5 and CCL2 expression and upregulates TNF, ICAM1,CCL3 expression (mRNA) in tumor neutrophiles (TAN)
PMID:23390297
MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD206, CD23