Protein ID3 map

Identifiers
HUGO:ID3

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE

References
 MACROPHAGE  map
 MDSC  map
CASCADE:LGALS1
CASCADE:IL10
PMID:21191065
regulatory effect of galectin-1 is mediated, in part, through its ability to induce, in an Id3 (inhibitor of DNA binding 3)-dependent manner, the expression of IL-10 in monocytes and MdDCs.
significantly increased IL-10 promoter activity was noted in CD14+ monocytes in the presence of A459-CM, NCI-H460-CM, or galectin-1. Increased IL-10 promoter activity was also found in cells overexpressing Id3

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. ID3@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rID3@INNATE_IMMUNE_CELL_Cytosol map → map ID3@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map