Protein IRF3 map

Identifiers
HUGO:IRF3

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:MIRNA_TF_IMMUNOSTIMULATORY

References
 MACROPHAGE  map
CASCADE:TGFB
CASCADE:STING
PMID:23422957
IKKa could regulate IRF3 activity and IRF3-dependent IFNβ and IL-12 production by DC. TAK1 (MAP3K7)-mediated IKKα/β activation is required for IRF3-dependent IFNβ expression in DC. At the same time IKKα regulates IRF3-mediated transcription downstream of IKKɛ/TBK1mediated IRF3 phosphorylation. IKKa increases the association of IRF3 with the transcriptional co-activator CBP. The increased recruitment of CBP after overexpression of IKKα was also associated with increased transcription of endogenous IFNβ mRNA.
PMID:22331441
Smad2/3 inhibited IFN-β production by suppressing IRF3 transcriptional activity.
Smad2/3 somehow suppresses IRF3 phosphorylation in macrophages..

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IRF3@INNATE_IMMUNE_CELL_Cytosol map
  2. IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CREBBP:​IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. IRF3@INNATE_IMMUNE_CELL_Cytosol map → map IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. CREBBP@INNATE_IMMUNE_CELL_Cytosol map + IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map → map CREBBP:​IRF3|​pho@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. gIFNB*@INNATE_IMMUNE_CELL_Cytosol map → map rINFB*@INNATE_IMMUNE_CELL_Cytosol map