Identifiers
HUGO:STAT3
Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:IMMUNE_SUPPRESSION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
References
MACROPHAGE
MDSC
DENDRITIC_CELL
NEUTROPHIL
CASCADE:IL10
CASCADE:FLT3LG
PMID:21383238
Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression.
PMID:16418395
FLT3L induces PU.1 and STAT3 mRNA expression in DC progenitors and downregulates GATA1 mRNA expression. At The same time enforced expression of STAT3 or PU.1 in DC progenitors led to the up-regulation of Flt3 mRNA levels, so there is a positive loop in this signaling. Enforced STAT3 or PU.1 expression instructs progenitors to differentiate into Dcs. Additionaly it induces expression mRNAs of cytokine receptors for G-CSF, M-CSF, and GM-CSF probably downstream of STAT3 ()
PMID:20237412
IFN-β regulates expression of homing and angiogenic factors in neutrophils.
IFNB downregulates expression Cxcr4, Vegf, and Mmp9 in neutrophils
additionally Stat3 and c-myc are downregulated by IFN-β.
(STAT3 is known to be required for full activation of the Cxcr4 gene )
→ rSTAT3@INNATE_IMMUNE_CELL_Cytosol
→ rSTAT3@INNATE_IMMUNE_CELL_Cytosol