Protein MAP2K4 map

Identifiers
HUGO:MAP2K4

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
 MACROPHAGE  map
CASCADE:TLR2_4
PMID:10465784
ECSIT (evolutionarilyconserved signaling intermediate inToll pathways), is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECSIT blocks MEKK-1 processing and activation of NF-κB
ECSIT mutant also strongly inhibited MEKK-1 activation of AP-1 (probably via MAP2K4/JNK),
additionally TRAF6-induced signaling is inhibited by dominant-negative constructs of MEKK-1.
PMID:17379190
MEK4/JNK/AP-1 path way is active in mactophages downstream of TLR4,
and induces iNOS expression.
PMID:15170913, PMID:9582321, PMID:11668179
MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway upregulates COX2 expression and PGE2 production in macrophages,
via activation of transcription factor C/EBP beta.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MAP2K4@INNATE_IMMUNE_CELL_Cytosol map
  2. MAP2K4|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MAP2K4@INNATE_IMMUNE_CELL_Cytosol map → map MAP2K4|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. JNK*@INNATE_IMMUNE_CELL_Cytosol map → map JNK*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
    2. p38*@INNATE_IMMUNE_CELL_Cytosol map → map p38*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map