Identifiers
HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14
REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11
REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12
REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13
REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14
Maps_Modules
NATURAL_KILLER
MACROPHAGE
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
CASCADE:IL10
CASCADE:KIR2DL4
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
CASCADE:TNF
CASCADE:TLR2_4
CASCADE:IL18
CASCADE:IFNG
References
PMID:11238627
SB203580, an inhibitor of the p38 MAPK, but not the extracellular signal-regulated kinase l/2 pathway blocker PD98059, inhibited the up-regulation of CD1a, CD40, CD80, CD86, HLA-DR, and the DC maturation marker CD83 induced by LPS and TNF-α.
PMID:11489965
The induction by KIR2DL4 of IFN-gamma production by resting NK cells was blocked by an inhibitor of the p38 mitogen-activated protein kinase signaling pathway
PMID:10961885, PMID:15345584, PMID:10903731
IL-12 and IL18 activate p38 in NK cells.
IFNG mRNA is stabilized by MAPK p38.
MAPK p38 signaling downstream of IL18 and IL 12 increases IFNG production.
PMID:10661401
MKK3 is activated by β1 Integrin Cross-Linking on Human NK Cells,
It activates p38MAPK regulated IL8 production by NK cells downstream of integrin signaling.
PMID:9379049
MKK3 and MKK4 are capable of phosphorylating p38mapk in macrophages,
downstream of TNF/Tnf receptor signaling.
PMID:15170913, PMID:9582321, PMID:11668179
MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway upregulates COX2 expression and PGE2 production in macrophages,
via activation of transcription factors C/EBP beta and CEBPD.
PMID:12048245
IFN-γ-Induced Gene Expression is MEKK1/p38 dependent and MEKK1/ERK dependent
MEKK1 upregulates CEBPB activation
PMID:11875494
IL10 stimulates HO1 expression via MAPK p38 stimulation. HO-1 mediates IL-10-induced suppression of TNF- production and IL-10-induced suppression of MMP9 expression.
PMID:22955274
SHIP inhibit MAPKp38 activation and prevent MNK1 phosphorylation by inhibiting the p38 MAPK pathway downstream of IL10. MNK1 regulates TNFa mRNA polysome assembly and upregulates TNFa translation.IL-10 Inhibits TNF Translation through SHIP1-mediated Inhibition of Mnk1
PMID:17073741
DUSP1 inhibits p38 and JNK pathways of innate innunity
PMID:16184516
Increased expression of DUSP1 in IL-10-treated activated macrophages was correlated with a faster down-regulation of p38 MAPK activation.
PMID:10606755
LPS and TNFalpha were found to induce the expression of SOCS3 mRNA in each of the investigated type of macrophages but not in HepG2 cells. Using a specific inhibitor, evidence is presented that the p38 MAP kinase might be involved, especially for the inhibitory effect of TNFalpha.
PMID:23681101, PMID:11477091
There are three main signaling pathways could be activated downstream of TRR4/MyD88/TAK1 signaling : p38 (via MKK3 or MKK6), JNK (via MKK4 or MKK7) and NfkB ) IN DC all these signaling pathways are activated downstream of TLR4 and TLR2 signaling )
PMID:23508573
HMGB1 induces activation (phosphorylation) of ERK, JNK and p38 via TLR4 in macrophages
PMID:11438547, PMID:24378531
in macrophages
Both TNFR1 and TNFR2 signaling pathways induce classical NFkB activation via IKBa degradation.
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.
Both TNFR1 and TNFR2 signaling pathways are needed for activation of p38 MAPK.
PMID:16713974, PMID:11579131
INFG pathway inhibits activation (phosphorylation) of ERK, JNK, p38 kinases and PI3K pathway induced by TLR. Inhibition of AKT pathway by IFNG resulted in activation of GSK3. GSK3 inhibits downstream AP-1 and CREB1 signaling and downregulates IL10 expression induced by TLR.IFNG inhibits CREB activation via p38 induced by TLR signaling
→ rHMOX1@INNATE_IMMUNE_CELL_Cytosol
→ rSOCS3@INNATE_IMMUNE_CELL_Cytosol
→ CREB1|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ MNK1|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ CD40@INNATE_IMMUNE_CELL_Membrane
→ CD80@INNATE_IMMUNE_CELL_Membrane
→ CD86@INNATE_IMMUNE_CELL_Membrane
→ CD83@INNATE_IMMUNE_CELL_Membrane
→ rIL8*@INNATE_IMMUNE_CELL_Cytosol
→ CD1*@INNATE_IMMUNE_CELL_Cytosol
→ IFNG@INNATE_IMMUNE_CELL_Cytosol
→ CEBPB|pho@INNATE_IMMUNE_CELL_Cytosol
→ rCEBPD@INNATE_IMMUNE_CELL_Cytosol