Identifiers
HUGO:HLA-DMA HUGO:HLA-DMB HUGO:HLA-DOA HUGO:HLA-DOB HUGO:HLA-DPA1 HUGO:HLA-DPB1 HUGO:HLA-DQA1 HUGO:HLA-DQA2 HUGO:HLA-DQB1 HUGO:HLA-DQB2 HUGO:HLA-DRA HUGO:HLA-DRB1 HUGO:HLA-DRB3 HUGO:HLA-DRB4 HUGO:HLA-DRB5
Maps_Modules
MODULE:IMMUNE_STIMULATION MODULE:ANTIGEN_PRESENTATION MODULE:EFFECTOR_ACTIVATION
References
DENDRITIC_CELL
MACROPHAGE
CASCADE:MIF
CASCADE:IL10
CASCADE:IFNG
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD206, CD23
PMID:22076556, PMID:22076556, PMID:25720354
Like MHC class I molecules, class II molecules are also heterodimers, but in this case consist of two homogenous peptides, an α and β chain, both of which are encoded in the MHC.
MHC class II molecules present antigen peptides to CD4+ T cells
PMID:7902377, PMID:1655948
IL-10 down-regulates not only the constitutive class 2 MHC expression on mono-
cytes , but also inhibites strongly the IL-13-induced
class 2 MHC expression .
PMID:8871614
IL13 induces MHC classe II expression via STAT6 pathway
CASCADE:CSF2
PMID: 19224634
STAT5 promotes expression of MHC class II transactivator protein (CIITA) and upregulates MHC class II expression downstream of CSF2
PMID: 8624807
IFN-γ has been shown to up-regulate MHC class II expression on dendritic cells.
Via CIITA.