Complex POLH:RAD18:RAD6*:REV1 map
Complex composition:

  1. POLH map
  2. REV1 map
  3. RAD6* map
  4. RAD18 map

POLH:​RAD18:​RAD6*:​REV1@default

Identifiers
NAME:POLH:RAD18:RAD6*:REV1

Maps_Modules
 dnarepair  map
 dnarepair  map

References
d_re236( dnarepair  map ):
Recruitment of all components as POLH and RAD6/RAD18 that ubiguitinate PCNA all together activate TLS:
PMID:16824193
d_re489( dnarepair  map ):
Reaction (id=re180, name=; CellCycle_DNArepair_18_12_2010_Version3.xml)
Phosphorilated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
PMID:17035102
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
PMID:19225445
REV1 interacts with many TLS polymerases:
PMID:14657033
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158
For TLS
PMID:19258535
FA core complex regulates REV1 and activated TLS
PMID:22266823

Confidence
REF=5 FUNC=5

Modifications:
Participates in complexes:
In compartment: default
  1. POLH:​RAD18:​RAD6*:​REV1@default map
Participates in reactions:
As Reactant or Product:
  1. RAD18:​RAD6*@default map + POLH@default map + REV1@default map → map POLH:​RAD18:​RAD6*:​REV1@default map
As Catalyser:
  1. gTLS_DNA_st1*@Nucleus map → map gTLS_DNA_st2*@Nucleus map