Identifiers
tumor protein p53
HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53

Maps_Modules
 emtcellmotility 
 apoptosis 
 apoptosis 
 dnarepair 
 dnarepair 
 cellcycle 
 survival 
 survival 
 survival 
 survival 

References
PMID:6396087, PMID:21340684, PMID:20457558, PMID:20182602, PMID:20066118

References
d_re34:( dnarepair  ) PMID:19788416
d_re226( dnarepair  ):
BRCA1 up-regulates transcription of GADD45 in p53 independed manner:
PMID:10367887, PMID:10962562
PMID:19004803, PMID:12496474
p53 enhances transcription of GADD45:
PMID:9892649, PMID:10779360
p53 regulated global genomic NER at the level of DNA damage recognition involving GADD45, XPC, DDB2:
PMID:12771027, PMID:9346961
d_re228( dnarepair  ):
BRCA1 enhances transcription of DDB2 in p53 independent manner
PMID:19004803, PMID:12496474, PMID:12170778
p53 enhances transcription of DDB2:
d_re231( dnarepair  ):
BRCA1 upregulates transcription of XPC in p53 independed manner:
p53 enhances transcription of XPC:
d_re344:( dnarepair  ) CHECKPOINT is p53_dependent_G1S_checkpoint

References
d_re34:( dnarepair  ) PMID:19788416
d_re48( dnarepair  ):
BRCA1 stabilises p53 and causes activation of p53-dependent DNA-repair genes and activation of checkpoint, but no apoptoss:
PMID:12024039 , PMID:12496474

1. p53*@default
2. p53*|​pho|​ace|​active@default

1. PARP1:​p53*@default

1. p53*@default → p53*|​pho|​ace|​active@default
2. p53*@default + PARP1|​PolyADPribose_unk|​pho@Nucleus → PARP1:​p53*@default
3. p53*@default → degraded

1. G1 phase@default → S phase@default
2. gGADD45*@default → rGADD45*@default
3. gDDB2@default → rDDB2@default
4. gXPC@default → rXPC@default
5. gCIP/KIP*@default → rCIP/KIP*@default
6. MAX@default + MYC@default → MAX:​MYC@default
7. g14-3-3*@default → r14-3-3*@default