Reaction known_transition_omitted d_re115 map

G1 phase@default map → S phase@default map

Reaction regulators:
Boolean_logic_gate_and
  1. MRE11*:​NBS1*|​S343_pho:​RAD50@default map and H2AFX:​PARP1@default map
Catalysis
  1. (CDK2|​T160_pho:​CyclinE*)|​active@default map
Inhibition
  1. FANCD2|​S222_pho@default map
  2. MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  3. CIP1_KIP1*@default map
  4. H2AFX:​PARP1@default map
  5. PARP1:​p53*@default map
  6. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​E2F1:​RB1@default map
  7. CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho:​RB1@default map
  8. (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@default map
  9. ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@default map
Trigger
  1. gRepaired_DNA*@Nucleus map


References
PMID:16581787,
For inhibition of S-checkpoint by ATM:
PMID:15175241
Inhibition of Sphase by MRE complex:
PMID:17713585
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S

Confidence
REF=2 FUNC=4