Reaction state_transition d_re65 map

CDC25A@default map → CDC25A|​S76_pho|​S178_pho|​S124_pho|​S279_pho|​S293_pho@default map

Reaction regulators:
Catalysis
  1. CHEK1|​pho|​active@default map
  2. CHEK2|​pho|​active@default map


References
Phosphorylation of CDC25A, B or C by CHEK1 and CHEK2 inactivates CDC25, prevents activating de-phosphorylation of CDKs by CDC25 A, B, C
and stops cell cycle propagation
kegg cell cycle
PMID:20126263, PMID:17568790

Confidence
REF=1 FUNC=5