Identifiers
CHK1 checkpoint homolog (S. pombe)
HUGO:CHEK1 HGNC:1925 ENTREZ:1111 UNIPROT:O14757 GENECARDS:CHEK1 REACTOME:87284 KEGG:1111 ATLASONC:GC_CHEK1 WIKI:CHEK1

Maps_Modules
 dnarepair 
 dnarepair 
 dnarepair 
 cellcycle 
 cellcycle 

References
For S-phase checkpoint
PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197

References
d_re33:( dnarepair  ) PMID:15485915
d_re34:( dnarepair  ) PMID:19788416
d_re65( dnarepair  ):
Phosphorylation of CDC25A, B or C by CHEK1 and CHEK2 inactivates CDC25, prevents activating de-phosphorylation of CDKs by CDC25 A, B, C
and stops cell cycle propagation
kegg cell cycle
PMID:20126263, PMID:17568790
d_re82:( dnarepair  ) PMID:21376743
d_re160( dnarepair  ):
PMID:18931676
PMID:19686080
Link between cell cycle and activation of Fanconi pathway
d_re186( dnarepair  ):
PMID:18931676, PMID:19686080
d_re187( dnarepair  ):
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723
d_re188( dnarepair  ):
PMID:18931676, PMID:19686080, PMID:17296736
d_re463( dnarepair  ):
Arrests cell cycle in S-phase in response to stalled replication fork or ds breaks in DNA:
PMID:15459660, PMID:17384638, PMID:19793801
d_re603( dnarepair  ):
In response to DNA damage, CHEK1 phosphorylates and activates WEE1, blocks cell cycle and allows DNA repair
PMID:23897299, PMID:23508805

References
d_re33:( dnarepair  ) PMID:15485915

1. CHEK1|​pho|​active@Nucleus

1. CHEK1@default
2. CHEK1|​pho|​active@default

1. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@default
2. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@default
3. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3:​TIM1*:​TIPIN@default

1. CHEK1@default → CHEK1|​pho|​active@default
2. HCLK2*@default + CLSPN|​pho@default + ATRIP:​ATR|​pho@default + CHEK1|​pho|​active@default → ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@default
3. TIM1*@default + CLSPN|​pho@default + PCNA|​K164_ubi@default + ATRIP:​ATR|​pho@default + CHEK1|​pho|​active@Nucleus → ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@default
4. ATRIP:​ATR|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3@default + TIPIN@default + TIM1*@default + CHEK1|​pho|​active@default → ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3:​TIM1*:​TIPIN@default
5. rCHEK1@default → CHEK1@default

1. S phase@default → G2 phase@default
2. FANCI@default → FANCI|​pho@default
3. gDamaged_DNA*@Nucleus → gRepaired_DNA*@Nucleus
4. FANCA@default → FANCA|​pho@default
5. FANCD2@default → FANCD2|​pho@default
6. FANCE@default → FANCE|​S376_pho|​T346_pho@default
7. FANCG@Nucleus → FANCG|​S7_pho@default
8. CDC25C@default → CDC25C|​S216_pho@default
9. p53*@default → p53*|​pho|​ace|​active@default
10. ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@default + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@default + CDT1@default + CDC6@default + CDC45@default + POLA*@default + PRIM*@default + RPA1@Nucleus + RPA2@Nucleus + RPA3@Nucleus → CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*:​RPA1:​RPA2:​RPA3@default
11. No DNA replicarion@default → DNA replicarion@default
12. WEE1@Nucleus → WEE1|​CHEK1site_pho@Nucleus
13. CDC25A@default → CDC25A|​S76_pho|​S178_pho|​S124_pho|​S279_pho|​S293_pho@default
14. CDC25B@default → CDC25B|​S230_pho|​S151_pho|​S323_pho@default
15. DNA-PK*@default → DNA-PK*|​pho@default