Reaction state_transition d_re110 map

CTIP*|​emp@default map → CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map

Reaction regulators:
Catalysis
  1. ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@default map
  2. ATR|​pho|​active@Nucleus map
Trigger
  1. gHR_DNA_st2*@Nucleus map


References
Phosphorylation by ATM and ATR at T847, S327
Phosphorylation at S327 by ATM and ATR are essential for shift from A_NHEJ to HR
Phosphorylation by CDC2(CDK1) in cell cycle dep manner to shift from C_NHEJ ot HR at: Ser 267
This phosphorylation allows resection that initiates HR and blocks binding of Ku70/Ku80 complex that initiates C_NHEJ.
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
BRCA1 and CtIP interactions make shift from A_NHEJ and C_NHEJ toward HR
Resected DNA in HR is a positive trigger for amplification of the HR pathway (positive loop):
PMID:20051983
Only when CDKs are fully active, this fully activates HR during S and G2 phases:
PMID:18511906, PMID:18716619

Confidence
REF=4 FUNC=4