CTIP*

Protein CTIP*

Identifiers
retinoblastoma binding protein 8 (RIM)
CTBP-interacting protein (CtIP)
HUGO:RBBP8 HGNC:9891 ENTREZ:5932 UNIPROT:Q99708 GENECARDS:RBBP8 REACTOME:62842 KEGG:5932 ATLASONC:RBBP8ID42066ch18q11 WIKI:RBBP8

Maps_Modules
dnarepair
dnarepair
dnarepair

References
PMID:17965729, PMID:9721205, PMID:19202191, PMID:18171986, PMID:20723763
For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ):
PMID:21376743, PMID:24050180, PMID:22743550

CTIP*|emp|S372_pho|T847_pho|S267_pho@default

References
d_re110( dnarepair ):
Phosphorylation by ATM and ATR at T847, S327
Phosphorylation at S327 by ATM and ATR are essential for shift from A_NHEJ to HR
Phosphorylation by CDC2(CDK1) in cell cycle dep manner to shift from C_NHEJ ot HR at: Ser 267
This phosphorylation allows resection that initiates HR and blocks binding of Ku70/Ku80 complex that initiates C_NHEJ.
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
BRCA1 and CtIP interactions make shift from A_NHEJ and C_NHEJ toward HR
Resected DNA in HR is a positive trigger for amplification of the HR pathway (positive loop):
PMID:20051983
Only when CDKs are fully active, this fully activates HR during S and G2 phases:
PMID:18511906, PMID:18716619
d_re118( dnarepair ):
BRCA1 ubiquitinates CtIP that allows propagation through G2 to M checkpoint
PMID:16818604
PMID:19357644

References
d_re118( dnarepair ):
BRCA1 ubiquitinates CtIP that allows propagation through G2 to M checkpoint
PMID:16818604
PMID:19357644
d_re121( dnarepair ):
The shift from C_NHEJ to HR is regulated by the CtIP and BRCA1. CDK1-dependent phosphorylation of CtIP regulates the shift: PMID:19357644
PMID:15485915

CTIP*|ubi@default

References
d_re111:( dnarepair ) PMID:14654780

CTIP*|emp@default

References
d_re110( dnarepair ):
Phosphorylation by ATM and ATR at T847, S327
Phosphorylation at S327 by ATM and ATR are essential for shift from A_NHEJ to HR
Phosphorylation by CDC2(CDK1) in cell cycle dep manner to shift from C_NHEJ ot HR at: Ser 267
This phosphorylation allows resection that initiates HR and blocks binding of Ku70/Ku80 complex that initiates C_NHEJ.
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
BRCA1 and CtIP interactions make shift from A_NHEJ and C_NHEJ toward HR
Resected DNA in HR is a positive trigger for amplification of the HR pathway (positive loop):
PMID:20051983
Only when CDKs are fully active, this fully activates HR during S and G2 phases:
PMID:18511906, PMID:18716619
d_re111:( dnarepair ) PMID:14654780
d_re122( dnarepair ):
PMID:20064462,
MRN complex in A_NHEJ: PMID:19362533, PMID:19654615, PMID:19892829

Modifications:
In compartment: default

CTIP*|emp@default
CTIP*|ubi@default
CTIP*|emp|S372_pho|T847_pho|S267_pho@default
CTIP*|emp|S372_pho|T847_pho|S267_pho|BRCA1-dep_ubi@default

Participates in complexes:
In compartment: Nucleus

ATM|S1981_pho|S367_pho|S1893_pho:CTIP*|emp:MRE11*:NBS1*|S343_pho:RAD50:WRN@Nucleus

In compartment: default

Participates in reactions:
As Reactant or Product:

As Catalyser: