ATM

Protein ATM

Identifiers
ataxia telangiectasia mutated
HUGO:ATM HGNC:795 ENTREZ:472 UNIPROT:Q13315 GENECARDS:ATM REACTOME:85553 KEGG:472 ATLASONC:ATM123 WIKI:ATM

Maps_Modules
emtcellmotility
apoptosis
dnarepair
dnarepair
dnarepair
cellcycle
cellcycle
cellcycle
survival

References
DDR by ATM
PMID:23847781
PMID:17303408, PMID:16163361, PMID:15964794
For S-phase checkpoint
PMID:15459660, PMID:12607003, PMID:11877377

ATM|S1981_pho|S367_pho|S1893_pho|active@default

References
d_re36( dnarepair ):
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707
d_re32:( dnarepair ) PMID:19788416, PMID:9168117, PMID:11804596
d_re33:( dnarepair ) PMID:15485915
d_re43:( dnarepair ) PMID:16731533
d_re71( dnarepair ):
For inactivation of EXO1 by 53BP1-mediated phosphorylation:
PMID:18756267, PMID:15867354
ATM and ATR phosphorylate EXO1 and lead to EXO1 ubiquitination and degradation:
PMID:18048416, PMID:11438669, PMID:20019063
d_re82:( dnarepair ) PMID:21376743
d_re97:( dnarepair ) PMID:17303408, PMID:16163361, PMID:15964794
d_re110( dnarepair ):
Phosphorylation by ATM and ATR at T847, S327
Phosphorylation at S327 by ATM and ATR are essential for shift from A_NHEJ to HR
Phosphorylation by CDC2(CDK1) in cell cycle dep manner to shift from C_NHEJ ot HR at: Ser 267
This phosphorylation allows resection that initiates HR and blocks binding of Ku70/Ku80 complex that initiates C_NHEJ.
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
BRCA1 and CtIP interactions make shift from A_NHEJ and C_NHEJ toward HR
Resected DNA in HR is a positive trigger for amplification of the HR pathway (positive loop):
PMID:20051983
Only when CDKs are fully active, this fully activates HR during S and G2 phases:
PMID:18511906, PMID:18716619
d_re115( dnarepair ):
PMID:16581787,
For inhibition of S-checkpoint by ATM:
PMID:15175241
Inhibition of Sphase by MRE complex:
PMID:17713585
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
d_re119( dnarepair ):
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
PMID:18469862
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
PMID:19342888
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
PMID:16713580
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767
d_re132:( dnarepair ) PMID:19841479, PMID:19793861
d_re148( dnarepair ):
PMID:18006705
PMID:18583988
d_re198( dnarepair ):
ATM phosphotylates FANCD2 for S-phase checkpoint arrest in responce to IR.
PMID:12086603
d_re408:( dnarepair ) PMID:9858600

ATM@default

Modifications:
In compartment: default

ATM@default
ATM|S1981_pho|S367_pho|S1893_pho|active@default

Participates in complexes:
In compartment: Nucleus

ATM|S1981_pho|S367_pho|S1893_pho:CTIP*|emp:MRE11*:NBS1*|S343_pho:RAD50:WRN@Nucleus

In compartment: default

Participates in reactions:
As Reactant or Product:

As Catalyser: