Reaction state_transition d_re156 map

gFanconi_DNA_st2*@Nucleus map → gFanconi_DNA_st3*@Nucleus map

Reaction regulators:
Boolean_logic_gate_and
  1. MRE11*:​NBS1*|​S343_pho:​RAD50@default map and BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map
Catalysis
  1. MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  2. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map
  3. WRN@Nucleus map
  4. RPA1:​RPA2:​RPA3@default map


References
MRN complex co-locolises at the FA foci and modulates propagation of ICL repair by Fanconi PMID:15136767, PMID:19622404
RPA is required for the replication fork block and remodeling toward DNA repair:
PMID:19622404
For role of SNM1B in Fanconi and S-phase checkpoint
PMID:18469862

Confidence
REF=1 FUNC=4