Complex RPA1:RPA2:RPA3
Complex composition:
- RPA2
- RPA1
- RPA3
RPA1:RPA2:RPA3@default
Identifiers
NAME:RPA1:RPA2:RPA3
Maps_Modules
dnarepair
dnarepair
References
d_re136( dnarepair
):
Regulation of HR DNA repair foci formation regulation by UBc13:
PMID:17349954
For role of SMARCAL1/RPA in stalled relication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862
MCM8*/MCM9* colocolize at RAD51 filament and reqired for interstrand crosslinks repair
PMID:22771115
d_re156( dnarepair
):
MRN complex co-locolises at the FA foci and modulates propagation of ICL repair by Fanconi PMID:15136767, PMID:19622404
RPA is required for the replication fork block and remodeling toward DNA repair:
PMID:19622404
For role of SNM1B in Fanconi and S-phase checkpoint
PMID:18469862
d_re355( dnarepair
):
For role of TIM1*/TIPIN in S-phase checkpoint, replication arrest, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
Confidence
REF=5 FUNC=5
RPA1:RPA2|pho:RPA3@default
Identifiers
NAME:RPA1:RPA2:RPA3
Maps_Modules
dnarepair
dnarepair
References
d_re45:( dnarepair
) PMID:16731533
Confidence
REF=1 FUNC=5
Modifications:
Participates in complexes:
In compartment: default
- RPA1:RPA2:RPA3@default
- RPA1:RPA2|pho:RPA3@default
Participates in reactions:
As Reactant or Product:- d_s2743 + d_s834 + EXO1@default
+ RPA1:RPA2:RPA3@default
+ PCNA@default
+ RFC*@Nucleus
→
EXO1:PCNA:RFC*:RPA1:RPA2:RPA3:hMutL*:hMutS*@Nucleus
- RPA1:RPA2:RPA3@default
+ SMARCAL1|pho@default
→
RPA1:RPA2:RPA3:SMARCAL1|pho@default
- CDK7:CyclinH*:MNAT1:TFIIH1*:TFIIH2*:TFIIH3*:TFIIH4*:TFIIH5*:XPB*:XPD*@default
+ RPA1:RPA2|pho:RPA3@default
+ XAB2:XPA|S196_pho@default
→
CDK7:CyclinH*:MNAT1:RPA1:RPA2|pho:RPA3:TFIIH1*:TFIIH2*:TFIIH3*:TFIIH4*:TFIIH5*:XAB2:XPA|S196_pho:XPB*:XPD*@default
- BRCA1|S988_pho|S1387_pho|S1423_pho|S1497_pho|S1524_pho|active@default
+ BRCA2@default
+ FANCJ*@default
+ RPA1:RPA2:RPA3@default
+ FANCN*@default
+ FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho@default
→
BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:FANCJ*:FANCN*:RPA1:RPA2:RPA3@default
- BLM:FAAP100*:FAAP20*:FAAP24*:FANCA|pho:FANCB:FANCC:FANCE|S376_pho|T346_pho:FANCF:FANCG|S7_pho:FANCL:FANCM:HES1@default
+ TOP3A@default
+ RPA1:RPA2:RPA3@default
→
BLM:FAAP100*:FAAP20*:FAAP24*:FANCA|pho:FANCB:FANCC:FANCE|S376_pho|T346_pho:FANCF:FANCG|S7_pho:FANCL:FANCM:HES1:RPA1:RPA2:RPA3:TOP3A@default
- POLE*@default
+ POLD*@default
+ RFC*@Nucleus
+ PCNA@default
+ CHTF18@default
+ POLK@default
+ XRCC1|pho@default
+ RPA1:RPA2|pho:RPA3@default
→
CHTF18:PCNA:POLD*:POLE*:POLK:RFC*:RPA1:RPA2|pho:RPA3:XRCC1|pho@default
- RAD52@default
+ RPA1:RPA2|pho:RPA3@default
→
RAD52:RPA1:RPA2|pho:RPA3@default
- RPA1@default
+ RPA2|pho@default
+ RPA3@default
→
RPA1:RPA2|pho:RPA3@default
- POLD*@default
+ RPA1:RPA2|pho:RPA3@default
→
POLD*:RPA1:RPA2|pho:RPA3@default
- ATRIP:ATR|pho@default
+ CLSPN|pho@default
+ RPA1:RPA2:RPA3@default
→
ATRIP:ATR|pho:CLSPN|pho:RPA1:RPA2:RPA3@default
- RPA1@default
+ RPA2@default
+ RPA3@default
→
RPA1:RPA2:RPA3@default
As Catalyser:- gHR_DNA_st2*@Nucleus
→
gHR_DNA_st3*@Nucleus
- gFanconi_DNA_st2*@Nucleus
→
gFanconi_DNA_st3*@Nucleus
- TOPBP1@default
+ ATRIP:ATR|pho@default
+ CLSPN|pho@default
+ RAD17|pho@default
→
ATRIP:ATR|pho:CLSPN|pho:RAD17|pho:TOPBP1@default
- ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*@default
+ MCM2:MCM3:MCM4:MCM5:MCM6:MCM7@default
+ CDT1@default
+ CDC6@default
+ CDC45@default
+ POLA*@default
+ PRIM*@default
+ RPA1@Nucleus
+ RPA2@Nucleus
+ RPA3@Nucleus
→
CDC45:CDC6:CDT1:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*:POLA*:PRIM*:RPA1:RPA2:RPA3@default