Identifiers
Werner syndrome, RecQ helicase-like
HUGO:WRN HGNC:12791 ENTREZ:7486 UNIPROT:Q14191 GENECARDS:WRN KEGG:7486 ATLASONC:WRNID284 WIKI:WRN

Maps_Modules
 dnarepair 
 dnarepair 
 dnarepair 

References
PMID:20691907
For A_NHEJ pathway
(alt_NHEJ or B_NHEJ or MMEJ)
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
, PMID:21376743, PMID:24050180, PMID:22743550
For HR pathway
PMID:19490890, PMID:22657828
For BER pathway
PMID:17116323, PMID:18398454, PMID:16449207, PMID:15385537, PMID:18558713, PMID:23161013
WRN in telomere maintenance
PMID:23253856
Resolving stalled replication fork
Inhibiting WNT kills alt_NHEJ pathway
PMID:24036544
PARP1 inhibits WRN
PMID:23082994
WRN inhibits C_NHEJ by sequestering DNA-PKs
PMID:12202749
Activation of WRN in cancers
http://www.intechopen.com/download/get/type/pdfs/id/22156
http://www.intechopen.com/download/get/type/pdfs/id/19301
PMID:18524993

References
d_re122( dnarepair  ):
PMID:20064462,
MRN complex in A_NHEJ: PMID:19362533, PMID:19654615, PMID:19892829
d_re566( dnarepair  ):
Binding between Ku70/80/DNA-PK and WRN inhibits Ku activity
PMID:17303082
PMID:12202749
WRN is a key activator of alt_NHEJ pathway
PMID:18524993
C_NHEJ and A_NHEJ are competing mechanisms
PMID:24050180

References
d_re564:( dnarepair  ) PMID:23082994

References
d_re22( dnarepair  ):
PMID:18398454
PMID:16449207
RECQL5 activates BER via XRCC1 and PARP1
PMID:22973052

1. WRN@Nucleus

1. WRN|​ace@default
2. WRN|​unk@default

1. DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus
2. ATM|​S1981_pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​MRE11*:​NBS1*|​S343_pho:​RAD50:​WRN@Nucleus

1. LIG3:​WRN@default
2. FEN1:​PCNA:​WRN@default
3. APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@default
4. PARP2|​unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default
5. PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default

1. ATM|​S1981_pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default + CTIP*|​emp@default + WRN@Nucleus → ATM|​S1981_pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​MRE11*:​NBS1*|​S343_pho:​RAD50:​WRN@Nucleus
2. LIG3@default + WRN@Nucleus → LIG3:​WRN@default
3. POLB@default + XRCC1|​pho@default + PARP1|​PolyADPribose_unk|​pho@Nucleus + WRN|​ace@default + PNK*@default → PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default
4. PCNA@default + FEN1@default + WRN@Nucleus → FEN1:​PCNA:​WRN@default
5. WRN@Nucleus → WRN|​ace@default
6. PARP2|​unk|​pho@default + WRN|​ace@default + PNK*@default + XRCC1|​pho@default + POLB@default → PARP2|​unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default
7. WRN@Nucleus → Telomere maintenance@Nucleus
8. WRN@Nucleus → WRN|​unk@default
9. Ku80*@default + Ku70*@default + WRN@Nucleus + DNA-PK*@default → DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus
10. Mg2+@default + APE*|​Thr233_pho|​ubi@default + PCNA@default + WRN@Nucleus → APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@default

1. gBER_M-glyc_DNA_st2*@Nucleus → gBER_M-glyc_DNA_st3*@Nucleus
2. gA_NHEJ_DNA_st1*@Nucleus → gA_NHEJ_DNA_st2*@Nucleus
3. gA_NHEJ_DNA_st5*@Nucleus → gA_NHEJ_DNA_st6*@Nucleus
4. gHR_DNA_st5*@Nucleus → gHR_DNA_st6*@Nucleus
5. gFanconi_DNA_st2*@Nucleus → gFanconi_DNA_st3*@Nucleus
6. gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + dNTPs@Nucleus → gShP_BER_M-glyc_st5_B-glyc_DNA_st5*@Nucleus
7. DNA-PK*@default → DNA-PK*|​hm2|​active@default
8. gBER_B-glyc_DNA_st3*@Nucleus → gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus + 3'ddR5P@default
9. gLnP_BER_M-glyc_st4*@Nucleus → gLnP_BER_M-glyc_st5*@Nucleus + Modified 2-12 nucl fragment@default