Reaction state_transition d_re316 map

CDC25C@default map → CDC25C|​S216_pho@default map

Reaction regulators:
Catalysis
  1. CHEK1|​pho|​active@default map
  2. CHEK2|​pho|​active@default map


References
Phosphorylation of CDC25A, B or C by CHEK1 and CHEK2 inactivates CDC25, prevents activating de-phosphorylation of CDKs by CDC25 A, B, C
and stops cell cycle propagation
kegg cell cycle
PMID:20126263, PMID:17568790

Confidence
REF=1 FUNC=5