Reaction transport re277 map

IRF3|​pho|​hm2@Cytoplasm map + P300@Cytoplasm map + CBP@Cytoplasm map → CBP:​IRF3|​pho|​hm2@Nucleus map

No reaction regulators




Phosphorylated IRF3 dimer translocates to the nucleus and associates with CBP/p300 to form a holocomplex. Phosphorylation at ser385, 386 are crucial for both homodimerisation and transactivation potetial of IRF3.
PMID:10920266; Suhara, W. et al. Analyses of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300. J Biochem (Tokyo) 128, 301-7 (2000).
PMID:9463386. Yoneyama M,Suhara W,Fukuhara Y,Fukuda M,Nishida E,Fujita T. Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. EMBO J. 1998 Feb 16;17(4):1087-95.