Protein TIFA

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Modifications:
In compartment: cytosol

1. TIFA@cytosol

Participates in complexes:
In compartment: cytosol

1. IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
2. IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
3. ECSIT:​IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
4. IRAK1|​T209_pho|​T387_pho|​ubi:​MEKK3:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
5. IRAK1|​T209_pho|​T387_pho|​ubi:​MEKK3|​pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
6. ASK1|​T845_pho:​IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
7. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
8. Ajuba:​IRAK1|​T209_pho|​T387_pho|​ubi:​PKC_zeta:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A:​p62@cytosol
9. IRAK1|​T209_pho|​T387_pho|​ubi:​TAB1:​TAB2_br_TAB3:​TAK1:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
10. Ajuba:​IRAK1|​T209_pho|​T387_pho|​ubi:​PKC_zeta|​T560_pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A:​p62@cytosol
11. IRAK1|​T209_pho|​T387_pho|​ubi:​TAB1:​TAB2_br_TAB3|​pho:​TAK1|​pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
12. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TIRAP:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol

Participates in reactions:
As Reactant or Product:

1. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol + TRAF6|​hm2@cytosol + TIFA@cytosol + Ubc13@cytosol + Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
2. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol → IRAK4:​MyD88|​hm2:​TIR domain@cytosol + IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
3. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TIRAP:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol → IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol + IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
4. IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
5. IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
6. IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol + TAB1:​TAB2_br_TAB3:​TAK1@cytosol → IRAK1|​T209_pho|​T387_pho|​ubi:​TAB1:​TAB2_br_TAB3:​TAK1:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
7. IRAK1|​T209_pho|​T387_pho|​ubi:​TAB1:​TAB2_br_TAB3:​TAK1:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho|​ubi:​TAB1:​TAB2_br_TAB3|​pho:​TAK1|​pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
8. IRAK1|​T209_pho|​T387_pho|​ubi:​TAB1:​TAB2_br_TAB3|​pho:​TAK1|​pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → TAB1:​TAB2_br_TAB3|​pho:​TAK1|​pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol + IRAK1|​T209_pho|​T387_pho|​ubi@cytosol + TIFA@cytosol
9. ECSIT@cytosol + IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → ECSIT:​IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
10. ASK1|​T845_pho|​active@cytosol + IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → ASK1|​T845_pho:​IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
11. IRAK1|​T209_pho|​T387_pho|​ubi:​MEKK3:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho|​ubi:​MEKK3|​pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
12. IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
13. TRAF6|​hm2@cytosol + IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol + Ubc13@cytosol + Uev1A@cytosol + TIFA@cytosol → IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TIRAP:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
14. MEKK3@cytosol + IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho|​ubi:​MEKK3:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
15. PKC_zeta:​p62@cytosol + IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol + Ajuba@cytosol → Ajuba:​IRAK1|​T209_pho|​T387_pho|​ubi:​PKC_zeta:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A:​p62@cytosol
16. Ajuba:​IRAK1|​T209_pho|​T387_pho|​ubi:​PKC_zeta:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A:​p62@cytosol → Ajuba:​IRAK1|​T209_pho|​T387_pho|​ubi:​PKC_zeta|​T560_pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A:​p62@cytosol

As Catalyser:

1. IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
2. full-length_br_MEKK1@cytosol → MEKK1@cytosol
3. MEKK1@cytosol → MEKK1*@cytosol
4. MKK6@cytosol → MKK6|​S207_pho|​active@cytosol
5. MKK3@cytosol → MKK3|​S189_pho|​T193_pho|​active@cytosol
6. MKK4@cytosol → MKK4|​S221_pho|​T225_pho|​active@cytosol
7. MKK7@cytosol → MKK7|​pho|​pho|​active@cytosol
8. Ajuba:​IRAK1|​T209_pho|​T387_pho|​ubi:​PKC_zeta:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A:​p62@cytosol → Ajuba:​IRAK1|​T209_pho|​T387_pho|​ubi:​PKC_zeta|​T560_pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A:​p62@cytosol
9. IKK_alpha|​hm2:​IKK_beta|​hm2:​IKK_gamma|​hm4@cytosol → (IKK_alpha|​hm2:​IKK_beta|​S177_pho|​S181_pho|​hm2:​IKK_gamma|​hm4)|​active@cytosol