Protein TRAF6

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Modifications:
In compartment: cytosol

1. TRAF6@cytosol
2. TRAF6|​hm2@cytosol
3. TRAF6|​ubi|​hm2@cytosol

Participates in complexes:
In compartment: cytosol

1. SIGIRR|​hm2:​TRAF6|​hm2@cytosol
2. PKR|​T451_pho|​T446_pho|​hm2:​TRAF6|​hm2@cytosol
3. SIGIRR:​TLR4:​TRAF6|​hm2@cytosol
4. SIGIRR:​TLR5:​TRAF6|​hm2@cytosol
5. SIGIRR:​TLR9:​TRAF6|​hm2@cytosol
6. RIP1:​TICAM1*:​TRAF6|​hm2@cytosol
7. IRF7:​MyD88|​hm2:​TRAF6|​hm2@cytosol
8. IRF7:​MyD88|​hm2:​TRAF6|​ubi|​hm2@cytosol
9. IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
10. IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
11. IRAK1c:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP:​TRAF6|​hm2@cytosol
12. TAB1:​TAB2_br_TAB3|​pho:​TAK1|​pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
13. TAB1:​TAB2_br_TAB3|​pho|​ubi:​TAK1|​pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
14. ECSIT:​IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
15. IRAK1|​T209_pho|​T387_pho|​ubi:​MEKK3:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
16. IRAK1|​T209_pho|​T387_pho|​ubi:​MEKK3|​pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
17. TAB1:​TAB2_br_TAB3|​pho|​ubi:​TAK1|​pho|​T187_pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
18. ASK1|​T845_pho:​IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
19. TAB1|​S423_pho|​S431_pho:​TAB2_br_TAB3|​pho|​ubi|​pho:​TAK1|​pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
20. TAB1|​S423_pho|​S431_pho:​TAB2_br_TAB3|​pho|​ubi|​pho:​TAK1|​pho|​T187_pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
21. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
22. Ajuba:​IRAK1|​T209_pho|​T387_pho|​ubi:​PKC_zeta:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A:​p62@cytosol
23. IRAK1|​T209_pho|​T387_pho|​ubi:​TAB1:​TAB2_br_TAB3:​TAK1:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
24. Ajuba:​IRAK1|​T209_pho|​T387_pho|​ubi:​PKC_zeta|​T560_pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A:​p62@cytosol
25. IRAK1|​T209_pho|​T387_pho|​ubi:​TAB1:​TAB2_br_TAB3|​pho:​TAK1|​pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
26. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TIRAP:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol

Participates in reactions:
As Reactant or Product:

1. TRAF6|​hm2@cytosol + PKR|​T451_pho|​T446_pho|​hm2|​active@cytosol → PKR|​T451_pho|​T446_pho|​hm2:​TRAF6|​hm2@cytosol
2. TICAM1*@cytosol + TRAF6|​hm2@cytosol + RIP1@cytosol → RIP1:​TICAM1*:​TRAF6|​hm2@cytosol
3. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain@cytosol + TRAF6|​hm2@cytosol + TIFA@cytosol + Ubc13@cytosol + Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
4. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol → IRAK4:​MyD88|​hm2:​TIR domain@cytosol + IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
5. IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TIRAP:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol → IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol + IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
6. IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
7. IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
8. IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol + TAB1:​TAB2_br_TAB3:​TAK1@cytosol → IRAK1|​T209_pho|​T387_pho|​ubi:​TAB1:​TAB2_br_TAB3:​TAK1:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
9. IRAK1|​T209_pho|​T387_pho|​ubi:​TAB1:​TAB2_br_TAB3:​TAK1:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho|​ubi:​TAB1:​TAB2_br_TAB3|​pho:​TAK1|​pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
10. IRAK1|​T209_pho|​T387_pho|​ubi:​TAB1:​TAB2_br_TAB3|​pho:​TAK1|​pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → TAB1:​TAB2_br_TAB3|​pho:​TAK1|​pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol + IRAK1|​T209_pho|​T387_pho|​ubi@cytosol + TIFA@cytosol
11. ECSIT@cytosol + IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → ECSIT:​IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
12. TRAF6@cytosol → TRAF6|​hm2@cytosol
13. ASK1|​T845_pho|​active@cytosol + IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → ASK1|​T845_pho:​IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
14. IRAK1|​T209_pho|​T387_pho|​ubi:​MEKK3:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho|​ubi:​MEKK3|​pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
15. IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
16. SIGIRR|​hm2@cytosol + TRAF6|​hm2@cytosol → SIGIRR|​hm2:​TRAF6|​hm2@cytosol
17. SIGIRR:​TLR5@cytosol + TRAF6|​hm2@cytosol → SIGIRR:​TLR5:​TRAF6|​hm2@cytosol
18. SIGIRR:​TLR4@cytosol + TRAF6|​hm2@cytosol → SIGIRR:​TLR4:​TRAF6|​hm2@cytosol
19. SIGIRR:​TLR9@cytosol + TRAF6|​hm2@cytosol → SIGIRR:​TLR9:​TRAF6|​hm2@cytosol
20. IRF7:​MyD88|​hm2:​TRAF6|​hm2@cytosol → IRF7:​MyD88|​hm2:​TRAF6|​ubi|​hm2@cytosol
21. IRF7:​MyD88|​hm2:​TRAF6|​ubi|​hm2@cytosol → IRF7|​S485_pho|​active@cytosol + MyD88|​hm2@cytosol + TRAF6|​ubi|​hm2@cytosol
22. MyD88|​hm2@cytosol + TRAF6|​hm2@cytosol + IRF7@cytosol → IRF7:​MyD88|​hm2:​TRAF6|​hm2@cytosol
23. IRAK1c:​TOLLIP@cytosol + TRAF6|​hm2@cytosol + IRAK4:​MyD88|​hm2:​TIR domain@cytosol → IRAK1c:​IRAK4:​MyD88|​hm2:​TIR domain:​TOLLIP:​TRAF6|​hm2@cytosol
24. TRAF6|​hm2@cytosol + IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIR domain:​TIRAP@cytosol + Ubc13@cytosol + Uev1A@cytosol + TIFA@cytosol → IRAK1|​T209_pho|​T387_pho:​IRAK4:​MyD88|​hm2:​TIFA:​TIR domain:​TIRAP:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol
25. MEKK3@cytosol + IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho|​ubi:​MEKK3:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
26. TAB1:​TAB2_br_TAB3|​pho:​TAK1|​pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → TAB1:​TAB2_br_TAB3|​pho|​ubi:​TAK1|​pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
27. TAB1:​TAB2_br_TAB3|​pho|​ubi:​TAK1|​pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → TAB1:​TAB2_br_TAB3|​pho|​ubi:​TAK1|​pho|​T187_pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
28. TAB1:​TAB2_br_TAB3|​pho|​ubi:​TAK1|​pho|​T187_pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → TAB1|​S423_pho|​S431_pho:​TAB2_br_TAB3|​pho|​ubi|​pho:​TAK1|​pho|​T187_pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
29. TAB1|​S423_pho|​S431_pho:​TAB2_br_TAB3|​pho|​ubi|​pho:​TAK1|​pho|​T187_pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → TAB1|​S423_pho|​S431_pho:​TAB2_br_TAB3|​pho|​ubi|​pho:​TAK1|​pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
30. PKC_zeta:​p62@cytosol + IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol + Ajuba@cytosol → Ajuba:​IRAK1|​T209_pho|​T387_pho|​ubi:​PKC_zeta:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A:​p62@cytosol
31. Ajuba:​IRAK1|​T209_pho|​T387_pho|​ubi:​PKC_zeta:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A:​p62@cytosol → Ajuba:​IRAK1|​T209_pho|​T387_pho|​ubi:​PKC_zeta|​T560_pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A:​p62@cytosol

As Catalyser:

1. IRAK1|​T209_pho|​T387_pho:​TIFA:​TRAF6|​hm2:​Ubc13:​Uev1A@cytosol → IRAK1|​T209_pho|​T387_pho|​ubi:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
2. IKK_alpha|​hm2:​IKK_beta|​hm2:​IKK_gamma|​hm4@cytosol → (IKK_alpha|​T23_pho|​hm2:​IKK_beta|​hm2:​IKK_gamma|​hm4)|​active@cytosol
3. full-length_br_MEKK1@cytosol → MEKK1@cytosol
4. NIK@cytosol → NIK|​pho|​active@cytosol
5. IRF7:​MyD88|​hm2:​TRAF6|​ubi|​hm2@cytosol → IRF7|​S485_pho|​active@cytosol + MyD88|​hm2@cytosol + TRAF6|​ubi|​hm2@cytosol
6. MEKK1@cytosol → MEKK1*@cytosol
7. MKK6@cytosol → MKK6|​S207_pho|​active@cytosol
8. p38_alpha_ MAPK@unknown → p38_alpha_ MAPK|​T180_pho|​Y182_pho|​active@unknown
9. Akt*|​S473_pho@cytosol → Akt*|​T308_pho|​S473_pho@cytosol
10. MKK3@cytosol → MKK3|​S189_pho|​T193_pho|​active@cytosol
11. MKK4@cytosol → MKK4|​S221_pho|​T225_pho|​active@cytosol
12. MKK7@cytosol → MKK7|​pho|​pho|​active@cytosol
13. TAB1:​TAB2_br_TAB3|​pho:​TAK1|​pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → TAB1:​TAB2_br_TAB3|​pho|​ubi:​TAK1|​pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
14. TAB1:​TAB2_br_TAB3|​pho|​ubi:​TAK1|​pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → TAB1:​TAB2_br_TAB3|​pho|​ubi:​TAK1|​pho|​T187_pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
15. TAB1|​S423_pho|​S431_pho:​TAB2_br_TAB3|​pho|​ubi|​pho:​TAK1|​pho|​T187_pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol → TAB1|​S423_pho|​S431_pho:​TAB2_br_TAB3|​pho|​ubi|​pho:​TAK1|​pho:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A@cytosol
16. Ajuba:​IRAK1|​T209_pho|​T387_pho|​ubi:​PKC_zeta:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A:​p62@cytosol → Ajuba:​IRAK1|​T209_pho|​T387_pho|​ubi:​PKC_zeta|​T560_pho:​TIFA:​TRAF6|​ubi|​hm2:​Ubc13:​Uev1A:​p62@cytosol
17. IKK_alpha|​hm2:​IKK_beta|​hm2:​IKK_gamma|​hm4@cytosol → (IKK_alpha|​hm2:​IKK_beta|​S177_pho|​S181_pho|​hm2:​IKK_gamma|​hm4)|​active@cytosol