Protein TRAF6 map

Identifiers
HUGO:TRAF6

Maps_Modules
 MACROPHAGE  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
CASCADE:TLR2_4
CASCADE:IL18

References
PMID:14660645, PMID:18264787, PMID:12620219
IRAK-1 interacts with the downstream adaptor TRAF6,
resulting in formation of a complex that also includes TAK1 and TAB2.
IRAK-1 mediates the translocation of TRAF6, TAK1 and TAB2 to the cytosol,
where they form a multiprotein complex with other cytosolic proteins,
which are needed for stimulation of TAK1 kinase activity.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TRAF6@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. TRAF6@INNATE_IMMUNE_CELL_Cytosol map → map TRAF6@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. MAP3K14@INNATE_IMMUNE_CELL_Cytosol map → map MAP3K14@INNATE_IMMUNE_CELL_Cytosol map
    2. MAP3K7@INNATE_IMMUNE_CELL_Cytosol map + TAB2@INNATE_IMMUNE_CELL_Cytosol map + TAB3@INNATE_IMMUNE_CELL_Cytosol map → map (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol map
    3. ECSIT@INNATE_IMMUNE_CELL_Cytosol map → map ECSIT@INNATE_IMMUNE_CELL_Cytosol map