Protein TAB2 map

Identifiers
HUGO:TAB2

Maps_Modules
 MACROPHAGE  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
CASCADE:TLR2_4
CASCADE:TNF

References
PMID:14660645, PMID:18264787, PMID:12620219
IRAK-1 interacts with the downstream adaptor TRAF6,
resulting in formation of a complex that also includes TAK1 and TAB2.
IRAK-1 mediates the translocation of TRAF6, TAK1 and TAB2 to the cytosol,
where they form a multiprotein complex with other cytosolic proteins,
which are needed for stimulation of TAK1 kinase activity.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TAB2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. MAP3K7@INNATE_IMMUNE_CELL_Cytosol map + TAB2@INNATE_IMMUNE_CELL_Cytosol map + TAB3@INNATE_IMMUNE_CELL_Cytosol map → map (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. IKK_alpha_*|​hm2@INNATE_IMMUNE_CELL_Cytosol map → map IKK_alpha_*|​pho|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map
  3. MAP2K4@INNATE_IMMUNE_CELL_Cytosol map → map MAP2K4|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. MAP2K3@INNATE_IMMUNE_CELL_Cytosol map → map MAP2K3|​pho@INNATE_IMMUNE_CELL_Cytosol map