Protein ECSIT map

Identifiers
HUGO:ECSIT

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
 MACROPHAGE  map
CASCADE:TLR2_4
PMID:25371197,
TAK1-ECSIT-TRAF6 Complex Plays a Key Role in the TLR4 Signal to Activate NF-κB
ECSIT-knockdown monocytic cells exhibited severe impairments in NF-κB activity, cytokine production, and NF-κB-dependent gene expression, whereas those were dramatically restored by reintroduction of wild type (WT) ECSIT gene.
IRF7, IL-1β, CD44, NF-κB2, IER3, IL-8, NF-κB1A, and RelB were markedly decreased in the ECSITKD
PMID:10465784
ECSIT (evolutionarilyconserved signaling intermediate inToll pathways), is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECSIT blocks MEKK-1 processing and activation of NF-κB
ECSIT mutant also strongly inhibited MEKK-1 activation of AP-1 (probably via MAP2K4/JNK),
additionally TRAF6-induced signaling is inhibited by dominant-negative constructs of MEKK-1.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. ECSIT@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. ECSIT@INNATE_IMMUNE_CELL_Cytosol map → map ECSIT@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. MAP3K7@INNATE_IMMUNE_CELL_Cytosol map + TAB2@INNATE_IMMUNE_CELL_Cytosol map + TAB3@INNATE_IMMUNE_CELL_Cytosol map → map (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol map
    2. MAP3K1@INNATE_IMMUNE_CELL_Cytosol map → map MAP3K1@INNATE_IMMUNE_CELL_Cytosol map