Protein CIITA map

Identifiers
HUGO:CIITA

Maps_Modules
MODULE:IMMUNE_STIMULATION MODULE:ANTIGEN_PRESENTATION MODULE:EFFECTOR_ACTIVATION

References
 DENDRITIC_CELL  map
 MACROPHAGE  map
CASCADE:IL4
CASCADE:CSF2
CASCADE:IFNG
PMID: 19224634
STAT5 promotes expression of MHC class II transactivator protein (CIITA) and upregulates MHC class II expression downstream of CSF2 (
PMID:8624807
CIITA is required for both constitutive and IFNγ-inducible expression of MHC class II genes
CIITA-deficient (−/−) mice do not express conventional MHC class II molecules on the surface of splenic B cells and dendritic cells.
PMID:11514596
Maturation of Dendritic Cells Is Accompanied by Rapid Transcriptional Silencing of Class II Transactivator (Ciita) Expression and
down regulation of MHCII expression.
PMID:22076556
CIITA expression is controlled in immature dendritic cells (DCs) by an activating transcriptional complex that contains PU.1, SP1, IRF8 and NF-κB, whereas it is inhibited in mature DCs by PR domain zinc finger protein 1 (PRDM1). Consequently, CIITA (with other factors) induces transcription of the MHC class II genes in immature DCs but not in mature DCs.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CIITA@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rCIITA@INNATE_IMMUNE_CELL_Cytosol map → map CIITA@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gMHC class II*@INNATE_IMMUNE_CELL_Cytosol map → map rMHC class II*@INNATE_IMMUNE_CELL_Cytosol map