Identifiers
HUGO:NCF1
Maps_Modules
MODULE:IMMUNE_STIMULATION MODULE:ANTIGEN_PRESENTATION MODULE:EFFECTOR_ACTIVATION MODULE:TUMOR_KILLING MODULE:NO_ROS_PRODUCTION
References
DENDRITIC_CELL
PMID:19372727
The enzyme responsible for O2•- production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation.
PMID:19380816, PMID:21383238
The increased ROS production by MDSC is mediated by up-regulated activity of NADPH oxidase (NOX2).
STAT3 upregulates expression of NOX2 subunits, primarily p47(NCF1) and gp91(CYBB) in MDSC,
In the absence of NOX2 activity, MDSC lost the ability to suppress T cell responses and quickly differentiated into mature macrophages and dendritic cells.
+ NCF2@INNATE_IMMUNE_CELL_Cytosol + NCF4@INNATE_IMMUNE_CELL_Cytosol + CYBA@INNATE_IMMUNE_CELL_Cytosol + NCF1@INNATE_IMMUNE_CELL_Cytosol + CYBB@INNATE_IMMUNE_CELL_Cytosol + FAD@INNATE_IMMUNE_CELL_Cytosol + heme@INNATE_IMMUNE_CELL_Cytosol → CYBA:CYBB:FAD:GTP:NCF1:NCF2:NCF4:RAC1_2*:heme@INNATE_IMMUNE_CELL_Cytosol