Protein SPI1 map

Identifiers
HUGO:SPI1

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:MIRNA_TF_IMMUNOSTIMULATORY

References
 DENDRITIC_CELL  map
 MACROPHAGE  map
CASCADE:MIF
CASCADE:FLT3LG
PMID:20510871
SPI1 (PU.1) is a critical regulator of both conventional and plasmacytoid DC development. It is directly upregulates Flt3 gene activation.
PMID:16418395
FLT3L induces PU.1 and STAT3 mRNA expression in DC progenitors and downregulates GATA1 mRNA expression.
PMID:16283355, PMID:12803886
MIF upregulates expression of TLR4 in macrothages via PU.1 (SPI1) activation
PMID:10734131
PU.1 (SPI1) together with IRF8 relulates TLR4 expression in myeloid cells ()

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. SPI1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GATA1:​SPI1@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. GATA1:​SPI1@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  2. GATA1@INNATE_IMMUNE_CELL_Cytosol map + SPI1@INNATE_IMMUNE_CELL_Cytosol map → map GATA1:​SPI1@INNATE_IMMUNE_CELL_Cytosol map
  3. rSPI1@INNATE_IMMUNE_CELL_Cytosol map → map SPI1@INNATE_IMMUNE_CELL_Cytosol map
  4. SPI1@INNATE_IMMUNE_CELL_Cytosol map → map SPI1@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. gTLR4@INNATE_IMMUNE_CELL_Cytosol map → map rTLR4@INNATE_IMMUNE_CELL_Cytosol map
  2. gFLT3@INNATE_IMMUNE_CELL_Cytosol map → map rFLT3@INNATE_IMMUNE_CELL_Cytosol map