RNA IL6 map

Identifiers
HUGO:IL6

Maps_Modules
 MACROPHAGE  map
 MDSC  map
MODULE:EFFECTOR_INHIBITION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_EXPRESSION
MODULE:IMMUNE_SUPPRESSION
CASCADE:STING
CASCADE:TLR2_4

References
PMID:17485448
Inhibition of‭ ‬NFkB signaling downstream of‭ ‬ABIN3‭ ‬
inhibits expression of‭ ‬IL8,‭ ‬IL6,‭ ‬TNF,‭ ‬IL12
PMID:15749903, PMID:16413922
NFKBID (IkBNS) interacts with NFkB p50 inhibit recrutement NFkB p50/p65 to IL-6 promoter
and inhibit IL6 expression.
PMID:9743347
IL-13 blocks NF-κB-dependent production of IL6
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
PMID:20093776
Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells via TLR2/MyD88 dependent IL6 expression.
PMID:18977329
IL-1β activates MDSC in vitro and in vivo through an IL-1RI/NF-κB pathway.
mRNA expression of several NF-κB target genes such is IL6, IL1B,TNF are IL1B/NFkB dependent in MSDC
PMID:17942936
IL-6 is a downstream mediator of the IL-1beta-induced expansion of MDSC

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rIL6@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rIL6@INNATE_IMMUNE_CELL_Cytosol map → map IL6@INNATE_IMMUNE_CELL_Cytosol map
    2. gIL6@INNATE_IMMUNE_CELL_Cytosol map → map rIL6@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: