Protein IL6 map

Identifiers
HUGO:IL6

Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:IMMUNE_SUPPRESSION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS MODULE:EFFECTOR_INHIBITION MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_EXPRESSION

References
 MACROPHAGE  map
 DENDRITIC_CELL  map
 MAST_CELL  map
CASCADE:IL6
CASCADE:TLR2_4
CASCADE:STING
CASCADE:FCAR
CASCADE:IL15
PMID:7590867
Fc alpha receptors mediate release of tumour necrosis factor-alpha and interleukin-6 by human monocytes following receptor aggregation
PMID:15573129, PMID:8837607, PMID:9845545
Macrophage colony-stimulating factor (M-CSF) and IL-6 have also been reported to be involved in the tumour-mediated regulation of DC differentiation.
PMID:15356132
The activation of STAT3 by IL-6 was required for the suppression of LPS-induced DC maturation. In addition, STAT3 was required for the IL-6-mediated suppression of bone-marrow-derived DC activation and/or maturation
PMID:11306493
The presence of high (>400 pg/ml) concentrations of IL-6 and M-CSF in tumor cell supernatant was strongly correlated with the inhibitory capacity of tumor cell medium on MO-DC differentiation
PMID:25582338
mIL-15 DCs secreted markedly greater amounts of proinflammatory cytokines, including IL-1α, IL-1β, IL-6, TNFα, TNFβ and IFN-γ, compared with mIL-4 DCs, suggesting that mIL-15 DCs are more proinflammatory than mIL-4 DCs.
The IFN-γ, TNFα and IL-6 transcripts were consistently expressed at higher levels at 330-, 14- and 20-folds, respectively, in donor-matched mIL-15 DCs than mIL-4 DCs
16286017 
IL-6-STAT3 Controls Intracellular MHC Class II αβ Dimer Level through Cathepsin S Activity in Dendritic Cells. IL-6 Stimulation via STAT3 Decreased Cystatin C Expression, Increased the Cathepsin S Activity, and Reduced the MHCII αβ Dimer Level in DCs In Vivo
PMID:15099563
Mast cells produce cytokines TNF-a, TGF-b, IFN-a, IL-1a, IL-1b, IL-5, IL-6,
IL-13, IL-16, IL-18

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IL6@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. IL6@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL6:​IL6R:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map
  2. IL6:​IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL6:​IL6R:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map IL6:​IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map
  2. IL6@INNATE_IMMUNE_CELL_Cytosol map → map IL6@default map
  3. IL6@default map + IL6R:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map → map IL6:​IL6R:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane map
  4. rIL6@INNATE_IMMUNE_CELL_Cytosol map → map IL6@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@default map
  2. JAK1@INNATE_IMMUNE_CELL_Cytosol map → map JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. TYK2@INNATE_IMMUNE_CELL_Cytosol map → map TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. JAK2@INNATE_IMMUNE_CELL_Cytosol map → map JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. STAT3@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map