Reaction transcription re560 map

gIL6@INNATE_IMMUNE_CELL_Cytosol map → rIL6@INNATE_IMMUNE_CELL_Cytosol map

Reaction regulators:
Catalysis
  1. HIF1A@INNATE_IMMUNE_CELL_Cytosol map
  2. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
Inhibition
  1. IKBKG:​IKK_alpha_*:​IKK_beta_*:​TNIP3@INNATE_IMMUNE_CELL_Cytosol map
  2. STING*@INNATE_IMMUNE_CELL_Cytosol map
  3. IRF4@INNATE_IMMUNE_CELL_Cytosol map





References
PMID:17485448
Inhibition of‭ ‬NFkB signaling downstream of‭ ‬ABIN3‭ ‬
inhibits expression of‭ ‬IL8,‭ ‬IL6,‭ ‬TNF,‭ ‬IL12
PMID:15749903, PMID:16413922
NFKBID (IkBNS) interacts with NFkB p50 inhibit recrutement NFkB p50/p65 to IL-6 promoter
and inhibit IL6 expression.
PMID:9743347
IL-13 blocks NF-κB-dependent production of IL6
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.