Protein CDH1 map

Identifiers
HUGO:CDH1

Maps_Modules
MODULE:INPUT_INHIBITORS MODULE:INHIBITION_OF_TUMOR_RECOGNITION MODULE:NK_INHIBITING_RECEPTORS

References
CASCADE:KLRG1
 NATURAL_KILLER  map
PMID:16461340, PMID:16424155, PMID:17617594
Killer cell lectin-like receptor G1 (KLRG1) is an inhibitory receptor expressed on subsets of natural killer (NK) cells.
Putative KLRG1 ligands are expressed ubiquitously in melanoma and carcinoma cell lines.1 binds three of the classical cadherins (E (CDH1), N (CDH2), and R(CDH4)).
E-cadherin binding of KLRG1 prevents the lysis of E-cadherin–expressing targets by KLRG1+ NK cells.
Tumor-associated E-cadherin mutations interfere with KLRG1 interaction, human KLRG1 failed to bind to Δ8 and Δ9 E-cadherin mutants.

Modifications:
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. CDH1@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CDH1:​CDH2:​CDH4:​KLRG1*|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CDH1@TUMOR_CELL_AS_INDUCTOR_Membrane map + KLRG1*@INNATE_IMMUNE_CELL_Membrane map + CDH2@TUMOR_CELL_AS_INDUCTOR_Membrane map + CDH4@TUMOR_CELL_AS_INDUCTOR_Membrane map → map CDH1:​CDH2:​CDH4:​KLRG1*|​pho@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@default map
  2. IFNG@INNATE_IMMUNE_CELL_Cytosol map → map IFNG@default map