Identifiers
HUGO:MTOR
Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
References
DENDRITIC_CELL
NATURAL_KILLER
PMID:16469695, PMID:26159692
mTOR Complex 1 (mTORC1) is composed of mTOR itself, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8 (MLST8) and the recently identified PRAS40 and DEPTOR
CASCADE:CSF2
CASCADE:IL15
PMID:25730849
L-10 Mediates β-Catenin–Dependent Inhibition of Cross-Priming,β-catenin enhanced IL-10 induction through mTOR pathway.
β-Catenin up-regulates level of mTOR in DCs and activates mTOR signaling.
PMID:18492954
mTOR regulates IL-12 expression
through an autocrine action of IL-10 in DC.
PMID:24973821, PMID:24795729
mTOR activity in NK cells is mainly under the control of IL-15.
mTOR deficiency profoundly impaired the early cytokine-driven activation of NK cells at multiple levels.
Inhibition of mTOR abrogates inflammation-induced priming.
mTOR controls the maturation and homeostasis of NK cells.
PI3K–AKT–mTOR pathway is required for granzyme B production downstream of IL15.
mTOR has positive influence on GZMA level in the NK cells.
and NK cells from rapamycin-treated mice (mTOR-inhibition) had attenuated lytic activities toward target tumor cells.
IL15 induces IFNG production via PI3K/AKT/MTOR pathway.
PMID:12906785, PMID:19022819
AKT activates Rapamycin associated protein FRAP2 ( mTOR ) probably through Tuberin/GTP-binding protein Ras homolog enriched in brain ( RHEB ) pathway.